دورية أكاديمية
Response assessment by combined PET-CT scan versus CT scan alone using RECIST in patients with locally advanced head and neck cancer treated with chemoradiotherapy
| العنوان: | Response assessment by combined PET-CT scan versus CT scan alone using RECIST in patients with locally advanced head and neck cancer treated with chemoradiotherapy |
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| المؤلفون: | Passero, V. A., Branstetter, B. F., Shuai, Y., Heron, D. E., Gibson, M. K., Lai, S. Y., Kim, S. W., Grandis, J. R., Ferris, R. L., Johnson, J. T., Argiris, A. |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2010 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | original article |
| الوصف: | Purpose: RECIST have limitations when applied to potentially curable locally advanced squamous cell carcinoma of the head and neck (SCCHN). [18F]fluorodeoxyglucose–positron emission tomography (PET) scan may be useful in assessing treatment response and predicting patient outcome. Patients and methods: We studied patients with previously untreated stages III–IVb SCCHN treated with primary concurrent chemoradiotherapy on five prospective clinical trials. Response was assessed by clinical exam, computed tomography (CT), and PET portions of combined PET–CT scan ∼8 weeks after completion of chemoradiotherapy. Results: Fifty-three patients were analyzed. Complete response (CR) was demonstrated in 42 patients (79%) by clinical exam, 15 (28%) by CT, and 27 (51%) by PET. CR as assessed by PET, but not as assessed by clinical exam or CT using RECIST, correlated significantly with progression-free status (PFS) ( P < 0.0001). The 2-year PFS for patients with CR and without CR by PET was 93% and 48%, respectively ( P = 0.0002). Conclusions: A negative PET scan on combined PET–CT after chemoradiotherapy is a powerful predictor of outcome in patients receiving curative chemoradiotherapy for SCCHN. PET–CT is indicated for response evaluation in this setting to improve the accuracy of post-treatment assessment by CT. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://annonc.oxfordjournals.org/cgi/content/short/mdq226v1Test; http://dx.doi.org/10.1093/annonc/mdq226Test |
| DOI: | 10.1093/annonc/mdq226 |
| الإتاحة: | https://doi.org/10.1093/annonc/mdq226Test http://annonc.oxfordjournals.org/cgi/content/short/mdq226v1Test |
| حقوق: | Copyright (C) 2010, European Society for Medical Oncology |
| رقم الانضمام: | edsbas.FF631052 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/annonc/mdq226 |
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