دورية أكاديمية
D3/Penta 21 clinical trial design: A randomised non-inferiority trial with nested drug licensing substudy to assess dolutegravir and lamivudine fixed dose formulations for the maintenance of virological suppression in children with HIV-1 infection, aged 2 to 15 years.
| العنوان: | D3/Penta 21 clinical trial design: A randomised non-inferiority trial with nested drug licensing substudy to assess dolutegravir and lamivudine fixed dose formulations for the maintenance of virological suppression in children with HIV-1 infection, aged 2 to 15 years. |
|---|---|
| المؤلفون: | Turkova, Anna, Chan, Man K, Kityo, Cissy, Kekitiinwa, Adeodata R, Musoke, Philippa, Violari, Avy, Variava, Ebrahim, Archary, Moherndran, Cressey, Tim R, Chalermpantmetagul, Suwalai, Sawasdichai, Kanokkorn, Ounchanum, Pradthana, Kanjanavanit, Suparat, Srirojana, Sakulrat, Srirompotong, Ussanee, Welch, Steven, Bamford, Alasdair, Epalza, Cristina, Fortuny, Clàudia, Colbers, Angela, Nastouli, Eleni, Walker, Simon, Carr, Dan, Conway, Magda, Spyer, Moira J, Parkar, Nazia, White, Iona, Nardone, Alessandra, Thomason, Margaret J, Ferrand, Rashida A, Giaquinto, Carlo, Ford, Deborah |
| المصدر: | Contemp Clin Trials ; ISSN:1559-2030 ; Volume:142 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Adolescents, Children, Dolutegravir/lamivudine, HIV, Randomised control trial, Two-drug therapy |
| الوصف: | There is increasing interest in utilising two-drug regimens for HIV treatment with the goal of reducing toxicity and improve acceptability. The D3 trial evaluates the efficacy and safety of DTG/3TC in children and adolescents and includes a nested pharmacokinetics(PK) substudy for paediatric drug licensing. |
| نوع الوثيقة: | article in journal/newspaper report |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.cct.2024.107540Test; https://pubmed.ncbi.nlm.nih.gov/38636725Test |
| DOI: | 10.1016/j.cct.2024.107540 |
| الإتاحة: | https://doi.org/10.1016/j.cct.2024.107540Test https://pubmed.ncbi.nlm.nih.gov/38636725Test |
| حقوق: | Copyright © 2023. Published by Elsevier Inc. |
| رقم الانضمام: | edsbas.FF06219 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.cct.2024.107540 |
|---|