دورية أكاديمية

Characterization of a spontaneous mouse model of mild, accelerated aging via ECM degradation in emphysematous lungs

التفاصيل البيبلوغرافية
العنوان: Characterization of a spontaneous mouse model of mild, accelerated aging via ECM degradation in emphysematous lungs
المؤلفون: Tanino, Ryosuke, Tsubata, Yukari, Hotta, Takamasa, Okimoto, Tamio, Amano, Yoshihiro, Takechi, Mayumi, Tanaka, Tetsuya, Akita, Tomomi, Nagase, Mamiko, Yamashita, Chikamasa, Wada, Koichiro, Isobe, Takeshi
المساهمون: GlaxoSmithKline Japan
المصدر: Scientific Reports ; volume 13, issue 1 ; ISSN 2045-2322
بيانات النشر: Springer Science and Business Media LLC
سنة النشر: 2023
مصطلحات موضوعية: Multidisciplinary
الوصف: Emphysema limits airflow and causes irreversible progression of chronic obstructive pulmonary disease (COPD). Strain differences must be considered when selecting mouse models of COPD, owing to disease complexity. We previously reported that a novel C57BL/6JJcl substrain, the Mayumi-Emphysema (ME) mouse, exhibits spontaneous emphysema; however, the other characteristics remain unknown. We aimed to characterize the lungs of ME mice and determine their experimental availability as a model. ME mice had a lower body weight than the control C57BL/6JJcl mice, with a median survival time of ~80 weeks. ME mice developed diffused emphysema with respiratory dysfunction from 8 to 26 weeks of age, but did not develop bronchial wall thickening. Proteomic analyses revealed five extracellular matrix-related clusters in downregulated lung proteins in ME mice. Moreover, EFEMP2/fibulin-4, an essential extracellular matrix protein, was the most downregulated protein in the lungs of ME mice. Murine and human EFEMP2 were detected in the pulmonary artery. Furthermore, patients with mild COPD showed decreased EFEMP2 levels in the pulmonary artery when compared to those without COPD. The ME mouse is a model of mild, accelerated aging with low-inflammatory emphysema and respiratory dysfunction that progresses with age and pulmonary EFEMP2 decrease, similar to that observed in patients with mild COPD.
نوع الوثيقة: article in journal/newspaper
اللغة: English
DOI: 10.1038/s41598-023-37638-4
الإتاحة: https://doi.org/10.1038/s41598-023-37638-4Test
https://www.nature.com/articles/s41598-023-37638-4.pdfTest
https://www.nature.com/articles/s41598-023-37638-4Test
حقوق: https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test
رقم الانضمام: edsbas.FEF53D30
قاعدة البيانات: BASE