دورية أكاديمية
Fixation Location and Stability in Best Vitelliform Macular Dystrophy
| العنوان: | Fixation Location and Stability in Best Vitelliform Macular Dystrophy |
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| المؤلفون: | Bianco, Lorenzo, Arrigo, Alessandro, Marchese, Alessandro, Antropoli, Alessio, Aragona, Emanuela, La Franca, Lamberto, Mauro, Luca, Pina, Adelaide, Hassan Farah, Rashid, Basile, Giulia, Bandello, Francesco, Battaglia Parodi, Maurizio |
| المساهمون: | Bianco, Lorenzo, Arrigo, Alessandro, Marchese, Alessandro, Antropoli, Alessio, Aragona, Emanuela, La Franca, Lamberto, Mauro, Luca, Pina, Adelaide, Hassan Farah, Rashid, Basile, Giulia, Bandello, Francesco, Battaglia Parodi, Maurizio |
| بيانات النشر: | ELSEVIER |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | BEST1, Best vitelliform macular dystrophy, Fixation eccentricity, Fixation stability, Mircoperimetry |
| الوصف: | Purpose: To analyze fixation location and stability in best vitelliform macular dystrophy (BVMD) and test their association with best-corrected visual acuity (BCVA).Design: Observational, cross-sectional study.Participants: Thirty patients (55 eyes) affected by genetically confirmed BVMD were followed up at the Retinal Heredodystrophies Unit of IRCCS San Raffaele Scientific Institute, Milan.Methods: Patients underwent testing with macular integrity assessment (MAIA) microperimeter. Fixation location was measured as distance in degrees (& DEG;) between preferred retinal locus (PRL) and estimated fovea location (EFL); fixation was defined as eccentric when the distance between PRL and EFL exceeded 2 & DEG;. Fixation stability was graded as stable, relatively unstable, or unstable and expressed as bivariate contour ellipse area (BCEA, & DEG;2).Main Outcome Measures: Fixation location and stability.Results: The median distance of the PRL from the anatomic fovea was 0.7 & DEG;, and fixation location was eccentric in 27% of eyes. Fixation was graded as stable in 64% of eyes, relatively unstable in 13%, and unstable in 24%, with a median 95% BCEA of 6.2 & DEG;2. The atrophic/fibrotic stage was associated with worse fixation pa-rameters (all P < 0.01). Both PRL eccentricity and fixation stability were linearly associated with BCVA: every 1 & DEG; increase in PRL eccentricity was associated with a 0.07 logarithm of the minimum angle of resolution (logMAR) worse BCVA (P < 0.0001) while every 1 & DEG;2 increase in 95% BCEA was associated with a 0.01 logMAR worse BCVA (P < 0.001). No significant intereye correlation was found for PRL eccentricity and fixation stability, as well as no association between the patient's age and fixation parameters.Conclusions: We demonstrated that most eyes affected by BVMD retain a central stable fixation and pro-vided evidence that both fixation eccentricity and stability are strongly associated with visual acuity in BVMD. These parameters may serve as ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37304042; info:eu-repo/semantics/altIdentifier/wos/WOS:001016685900001; volume:3; issue:4; firstpage:100329; journal:OPHTHALMOLOGY SCIENCE; https://hdl.handle.net/20.500.11768/148716Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85161081709; https://www.ophthalmologyscience.org/article/S2666-9145Test(23)00061-1/fulltext |
| DOI: | 10.1016/j.xops.2023.100329 |
| الإتاحة: | https://doi.org/20.500.11768/148716Test https://doi.org/10.1016/j.xops.2023.100329Test https://hdl.handle.net/20.500.11768/148716Test https://www.ophthalmologyscience.org/article/S2666-9145Test(23)00061-1/fulltext |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.FEA910EF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.xops.2023.100329 |
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