دورية أكاديمية
Preferences and acceptability for long‐acting PrEP agents among pregnant and postpartum women with experience using daily oral PrEP in South Africa and Kenya
| العنوان: | Preferences and acceptability for long‐acting PrEP agents among pregnant and postpartum women with experience using daily oral PrEP in South Africa and Kenya |
|---|---|
| المؤلفون: | Nafisa J. Wara, Rufaro Mvududu, Mary M. Marwa, Laurén Gómez, Nyiko Mashele, Catherine Orrell, Corrina Moucheraud, John Kinuthia, Grace John‐Stewart, Landon Myer, Risa Hoffman, Jillian Pintye, Dvora L. Joseph Davey |
| المصدر: | Journal of the International AIDS Society, Vol 26, Iss 5, Pp n/a-n/a (2023) |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | breastfeeding, long‐acting, PrEP, pregnancy, Kenya, South Africa, Immunologic diseases. Allergy, RC581-607 |
| الوصف: | Introduction Long‐acting pre‐exposure prophylaxis (PrEP) options could overcome barriers to oral PrEP persistence during pregnancy and postpartum. We evaluated long‐acting PrEP preferences among oral PrEP‐experienced pregnant and postpartum women in South Africa and Kenya, countries with high PrEP coverage with pending regulatory approvals for long‐acting injectable cabotegravir and the dapivirine vaginal ring (approved in South Africa, under review in Kenya). Methods From September 2021 to February 2022, we surveyed pregnant and postpartum women enrolled in oral PrEP studies in South Africa and Kenya. We evaluated oral PrEP attitudes and preferences for long‐acting PrEP methods in multivariable logistic regression models adjusting for maternal age and country. Results We surveyed 190 women in South Africa (67% postpartum; median age 27 years [IQR = 22–32]) and 204 women in Kenya (79% postpartum; median age 29 years [IQR = 25–33]). Seventy‐five percent of participants reported oral PrEP use within the last 30 days. Overall, forty‐nine percent of participants reported negative oral PrEP attributes, including side effects (21% South Africa, 30% Kenya) and pill burden (20% South Africa, 25% Kenya). Preferred PrEP attributes included long‐acting method, effectiveness, safety while pregnant and breastfeeding, and free medication. Most participants (75%, South Africa and Kenya) preferred a potential long‐acting injectable over oral PrEP, most frequently for a longer duration of effectiveness in South Africa (87% South Africa, 42% Kenya) versus discretion in Kenya (5% South Africa, 49% Kenya). Eighty‐seven percent of participants preferred oral PrEP over a potential long‐acting vaginal ring, mostly due to concern about possible discomfort with vaginal insertion (82% South Africa, 48% Kenya). Significant predictors of long‐acting PrEP preference included past use of injectable contraceptive (aOR = 2.48, 95% CI: 1.34, 4.57), disliking at least one oral PrEP attribute (aOR = 1.72, 95% CI: 1.05, 2.80) and ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1758-2652 |
| العلاقة: | https://doi.org/10.1002/jia2.26088Test; https://doaj.org/toc/1758-2652Test; https://doaj.org/article/ed5eee03cb3a46209819255e36207d11Test |
| DOI: | 10.1002/jia2.26088 |
| الإتاحة: | https://doi.org/10.1002/jia2.26088Test https://doaj.org/article/ed5eee03cb3a46209819255e36207d11Test |
| رقم الانضمام: | edsbas.FE26324C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17582652 |
|---|---|
| DOI: | 10.1002/jia2.26088 |