دورية أكاديمية
Discordance Between Coronary Artery Calcium Area and Density Predicts Long-Term Atherosclerotic Cardiovascular Disease Risk
| العنوان: | Discordance Between Coronary Artery Calcium Area and Density Predicts Long-Term Atherosclerotic Cardiovascular Disease Risk |
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| المؤلفون: | Razavi, Alexander C, van Assen, Marly, De Cecco, Carlo N, Dardari, Zeina A, Berman, Daniel S, Budoff, Matthew J, Miedema, Michael D, Nasir, Khurram, Rozanski, Alan, Rumberger, John A, Shaw, Leslee J, Sperling, Laurence S, Whelton, Seamus P, Mortensen, Martin Bødtker, Blaha, Michael J, Dzaye, Omar |
| المصدر: | Razavi , A C , van Assen , M , De Cecco , C N , Dardari , Z A , Berman , D S , Budoff , M J , Miedema , M D , Nasir , K , Rozanski , A , Rumberger , J A , Shaw , L J , Sperling , L S , Whelton , S P , Mortensen , M B , Blaha , M J & Dzaye , O 2022 , ' Discordance Between Coronary Artery Calcium Area and Density Predicts Long-Term Atherosclerotic Cardiovascular Disease Risk ' , JACC: Cardiovascular Imaging .... |
| سنة النشر: | 2022 |
| المجموعة: | Aarhus University: Research |
| مصطلحات موضوعية: | calcium density, cardiovascular diseases, coronary artery calcium, multidetector computed tomography, Predictive Value of Tests, Calcium, Risk Assessment, Humans, Middle Aged, Risk Factors, Male, Coronary Artery Disease, Plaque, Atherosclerotic, Cardiovascular Diseases/pathology, Female, Atherosclerosis/pathology, Coronary Vessels/diagnostic imaging, Vascular Calcification |
| الوصف: | Background: Coronary artery calcium (CAC) is commonly quantified as the product of 2 generally correlated measures: plaque area and calcium density. Objectives: The authors sought to determine whether discordance between calcium area and density has long-term prognostic importance in atherosclerotic cardiovascular disease (ASCVD) risk. Methods: The authors studied 10,373 primary prevention participants from the CAC Consortium with CAC >0. Based on their median values, calcium area and mean calcium density were divided into 4 mutually exclusive concordant/discordant groups. Cox proportional hazards regression assessed the association of calcium area/density groups with ASCVD mortality over a median of 11.7 years, adjusting for traditional risk factors and the Agatston CAC score. Results: The mean age was 56.7 years, and 24% were female. The prevalence of plaque discordance was 19% (9% low calcium area/high calcium density, 10% high calcium area/low calcium density). Female sex (odds ratio [OR]: 1.48 [95% CI: 1.27-1.74]) and body mass index (OR: 0.81 [95% CI: 0.76-0.87], per 5 kg/m 2 higher) were significantly associated with high calcium density discordance, whereas diabetes (OR: 2.23 [95% CI: 1.85-3.19]) was most strongly associated with discordantly low calcium density. Compared to those with low calcium area/low calcium density, individuals with low calcium area/high calcium density had a 71% lower risk of ASCVD death (HR: 0.29 [95% CI: 0.09-0.95]). Conclusions: For a given CAC score, high calcium density relative to plaque area confers lower long-term ASCVD risk, likely serving as an imaging marker of biological resilience for lesion vulnerability. Additional research is needed to define a robust definition of calcium area/density discordance for routine clinical risk prediction. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://pure.au.dk/portal/en/publications/a15cec32-b5ec-44e0-9900-5035aa2d3b0cTest |
| DOI: | 10.1016/j.jcmg.2022.06.007 |
| الإتاحة: | https://doi.org/10.1016/j.jcmg.2022.06.007Test https://pure.au.dk/portal/en/publications/a15cec32-b5ec-44e0-9900-5035aa2d3b0cTest https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883836/pdf/nihms-1867586.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.FD9CC34D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jcmg.2022.06.007 |
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