دورية أكاديمية
Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity-Diverse effects on cell growth, metabolism and cancer
| العنوان: | Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity-Diverse effects on cell growth, metabolism and cancer |
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| المؤلفون: | Mccubrey, J., Rakus, D., Gizak, A., Steelman, L., Abrams, S., Lertpiriyapong, K., Fitzgerald, T., Yang, L., MONTALTO, Giuseppe, Cervello, M., Libra, M., Nicoletti, F., Scalisi, A., Torino, F., Fenga, C., Neri, L., Marmiroli, S., Cocco, L., Martelli, A. |
| المساهمون: | Mccubrey, J., Rakus, D., Gizak, A., Steelman, L., Abrams, S., Lertpiriyapong, K., Fitzgerald, T., Yang, L., Montalto, G., Cervello, M., Libra, M., Nicoletti, F., Scalisi, A., Torino, F., Fenga, C., Neri, L., Marmiroli, S., Cocco, L., Martelli, A. |
| سنة النشر: | 2016 |
| المجموعة: | IRIS Università degli Studi di Palermo |
| مصطلحات موضوعية: | Akt, GSK-3, Hedgehog, Notch, PI3K, Targeted therapy, Therapy resistance, Wnt/beta-catenin, mTOR |
| الوصف: | Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that participates in an array of critical cellular processes. GSK-3 was first characterized as an enzyme that phosphorylated and inactivated glycogen synthase. However, subsequent studies have revealed that this moon-lighting protein is involved in numerous signaling pathways that regulate not only metabolism but also have roles in: apoptosis, cell cycle progression, cell renewal, differentiation, embryogenesis, migration, regulation of gene transcription, stem cell biology and survival. In this review, we will discuss the roles that GSK-3 plays in various diseases as well as how this pivotal kinase interacts with multiple signaling pathways such as: PI3K/PTEN/Akt/mTOR, Ras/Raf/MEK/ERK, Wnt/beta-catenin, hedgehog, Notch and TP53. Mutations that occur in these and other pathways can alter the effects that natural GSK-3 activity has on regulating these signaling circuits that can lead to cancer as well as other diseases. The novel roles that microRNAs play in regulation of the effects of GSK-3 will also be evaluated. Targeting GSK-3 and these other pathways may improve therapy and overcome therapeutic resistance. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27612668; info:eu-repo/semantics/altIdentifier/wos/WOS:000388049500008; volume:1863; issue:12; firstpage:2942; lastpage:2976; numberofpages:35; journal:BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR CELL RESEARCH; http://hdl.handle.net/10447/199956Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84989199369 |
| DOI: | 10.1016/j.bbamcr.2016.09.004 |
| الإتاحة: | https://doi.org/10.1016/j.bbamcr.2016.09.004Test http://hdl.handle.net/10447/199956Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.FCD95E6B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.bbamcr.2016.09.004 |
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