دورية أكاديمية
Lipid Metabolic Disorders Induced by Organophosphate Esters in Silver Carp from the Middle Reaches of the Yangtze River
| العنوان: | Lipid Metabolic Disorders Induced by Organophosphate Esters in Silver Carp from the Middle Reaches of the Yangtze River |
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| المؤلفون: | Chunsheng Liu, Zihan Zhang, Boqun Li, Kai Huang, Yongkang Zhang, Meng Li, Robert J. Letcher |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Biophysics, Biochemistry, Genetics, Molecular Biology, Physiology, Pharmacology, Inorganic Chemistry, Mental Health, Computational Biology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, provided mechanistic insights, one suspected reason, induced metabolic disorders, hypophthalmichthys molitrix ), fatty acid biosynthesis, total lipid levels, silver carp captured, opes significantly increased, including silver carp, silver carp, steroid biosynthesis, significantly changed, lipid metabolism, lipid homeostasis, yangtze river, wild fish, signal pathway, results indicated, positively associated |
| الوصف: | The Yangtze River fishery resources have declined strongly over the past few decades. One suspected reason for the decline in fishery productivity, including silver carp (Hypophthalmichthys molitrix), has been linked to organophosphate esters (OPEs) contaminant exposure. In this study, the adverse effect of OPEs on lipid metabolism in silver carp captured from the Yangtze River was examined, and our results indicated that muscle concentrations of the OPEs were positively associated with serum cholesterol and total lipid levels. In vivo laboratory results revealed that exposure to environmental concentrations of OPEs significantly increased the concentrations of triglyceride, cholesterol, and total lipid levels. Lipidome analysis further confirmed the lipid metabolism dysfunction induced by OPEs, and glycerophospholipids and sphingolipids were the most affected lipids. Hepatic transcriptomic analysis found that OPEs caused significant alterations in the transcription of genes involved in lipid metabolism. Pathways associated with lipid homeostasis, including the peroxisome proliferator-activated receptor (PPAR) signal pathway, cholesterol metabolism, fatty acid biosynthesis, and steroid biosynthesis, were significantly changed. Furthermore, the affinities of OPEs were different, but the 11 OPEs tested could bind with PPARγ, suggesting that OPEs could disrupt lipid metabolism by interacting with PPARγ. Overall, this study highlighted the harmful effects of OPEs on wild fish and provided mechanistic insights into OPE-induced metabolic disorders. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/journal_contribution/Lipid_Metabolic_Disorders_Induced_by_Organophosphate_Esters_in_Silver_Carp_from_the_Middle_Reaches_of_the_Yangtze_River/25336432Test |
| DOI: | 10.1021/acs.est.3c08610.s001 |
| الإتاحة: | https://doi.org/10.1021/acs.est.3c08610.s001Test https://figshare.com/articles/journal_contribution/Lipid_Metabolic_Disorders_Induced_by_Organophosphate_Esters_in_Silver_Carp_from_the_Middle_Reaches_of_the_Yangtze_River/25336432Test |
| حقوق: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.FC8843D1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.est.3c08610.s001 |
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