دورية أكاديمية
Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation.
| العنوان: | Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation. |
|---|---|
| المؤلفون: | Wiesner, Darin L, Merkhofer, Richard M, Ober, Carole, Kujoth, Gregory C, Niu, Mengyao, Keller, Nancy P, Gern, James E, Brockman-Schneider, Rebecca A, Evans, Michael D, Jackson, Daniel J, Warner, Thomas, Jarjour, Nizar N, Esnault, Stephane J, Feldman, Michael B, Freeman, Matthew, Mou, Hongmei, Vyas, Jatin M, Klein, Bruce S |
| المساهمون: | Université de Lille, Inserm, CHU Lille |
| سنة النشر: | 2020 |
| المجموعة: | LillOA (Lille Open Archive - Université de Lille) |
| مصطلحات موضوعية: | Allergens, Animals, Aspergillus fumigatus, Asthma, Bronchioles, Calcineurin, Calcium Channels, Calcium Signaling, Cohort Studies, Eosinophilia, Epithelial Cells, Humans, Inflammation, Mice, Inbred C57BL, Serine Endopeptidases, T-Lymphocytes, TRPV Cation Channels, Aspergillus, TRPV4, alkaline protease 1, asthma, calcineurin, calcium, club cells |
| الوصف: | Airway epithelium is the first body surface to contact inhaled irritants and report danger. Here, we report how epithelial cells recognize and respond to aeroallergen alkaline protease 1 (Alp1) of Aspergillus sp., because proteases are critical components of many allergens that provoke asthma. In a murine model, Alp1 elicits helper T (Th) cell-dependent lung eosinophilia that is initiated by the rapid response of bronchiolar club cells to Alp1. Alp1 damages bronchiolar cell junctions, which triggers a calcium flux signaled through calcineurin within club cells of the bronchioles, inciting inflammation. In two human cohorts, we link fungal sensitization and/or asthma with SNP/protein expression of the mechanosensitive calcium channel, TRPV4. TRPV4 is also necessary and sufficient for club cells to sensitize mice to Alp1. Thus, club cells detect junction damage as mechanical stress, which signals danger via TRPV4, calcium, and calcineurin to initiate allergic sensitization. ; 27 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Cell Host & Microbe; Cell Host Microbe; http://hdl.handle.net/20.500.12210/88585Test |
| الإتاحة: | https://doi.org/20.500.12210/88585Test https://hdl.handle.net/20.500.12210/88585Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.FC588C82 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |