دورية أكاديمية
The Research Progress of Bufalin in the Treatment of Hepatocellular Carcinoma
| العنوان: | The Research Progress of Bufalin in the Treatment of Hepatocellular Carcinoma |
|---|---|
| المؤلفون: | Jiang,Han-yu, Zheng,Hui-min, Xia,Cheng, Li,Xiang, Wang,Gang, Zhao,Tong, Cui,Xiao-nan, Wang,Ruo-yu, Liu,Ying |
| بيانات النشر: | Dove Press |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | OncoTargets and Therapy, psy, socio |
| الوصف: | Han-yu Jiang,1,* Hui-min Zheng,1,* Cheng Xia,1 Xiang Li,1 Gang Wang,1 Tong Zhao,1 Xiao-nan Cui,2 Ruo-yu Wang,1,3 Ying Liu1,3 1Department of Oncology, The Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, People’s Republic of China; 2Department of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 3The Key Laboratory of Biomarker High Throughput Screening and Target Translation of Breast and Gastrointestinal Tumor, Dalian, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ying Liu, Department of Oncology, The Affiliated Zhongshan Hospital of Dalian University, Dalian, People’s Republic of China, Tel +8615942653462, Fax +86 411-62893555 Email ly_janet198862@sina.com Ruo-yu Wang, Department of Oncology, The Affiliated Zhongshan Hospital of Dalian University, No. 6, Liberation Street, Zhongshan District, Dalian, 116001, People’s Republic of China, Tel +86071762897187, Fax +86 411-62893555, Email wangruoyu1963@163.comAbstract: Hepatocellular carcinoma (HCC) is one of the deadliest cancers in the world with a five-year survival rate of less than 20%. Nonetheless, selecting an appropriate therapeutic agent to inhibit the development of hepatoma cells is still a challenge. Bufalin, a component of the traditional Chinese medicine Chansu, has been shown to inhibit the proliferation, invasion and metastasis of HCC through various signaling pathways. In addition, bufalin and sorafenib demonstrate a synergistic effect in cancer therapeutics. This review highlighted on several focal signaling pathways involved in the inhibitory effects of bufalin on HCC and its synergistic mechanisms with sorafenib. The immunotherapy effect of bufalin has also been discussed as a novel property.Keywords: bufalin, cancer, therapy, signaling pathways, immunotherapy effect |
| نوع الوثيقة: | article in journal/newspaper review |
| اللغة: | English |
| العلاقة: | https://www.dovepress.com/the-research-progress-of-bufalin-in-the-treatment-of-hepatocellular-ca-peer-reviewed-fulltext-article-OTTTest |
| الإتاحة: | https://www.dovepress.com/the-research-progress-of-bufalin-in-the-treatment-of-hepatocellular-ca-peer-reviewed-fulltext-article-OTTTest |
| حقوق: | undefined |
| رقم الانضمام: | edsbas.FBF74C3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |