دورية أكاديمية
At1 receptor blockade improves myocardial functional performance in obesity ; Bloqueio de Receptores AT1 Melhora o Desempenho Funcional Miocárdico na Obesidade
| العنوان: | At1 receptor blockade improves myocardial functional performance in obesity ; Bloqueio de Receptores AT1 Melhora o Desempenho Funcional Miocárdico na Obesidade |
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| المؤلفون: | de Oliveira-Junior, Silvio Assis, Muzili, Nayara de Araújo, Carvalho, Marianna Rabelo de, Ota, Gabriel Elias, de Morais, Camila Souza, Vieira, Larissa Fregapani da Costa, Ortiz, Mateus Oliveira, Campos, Dijon H. S., Cezar, Marcelo Diacardia Mariano, Okoshi, Marina Politi, Okoshi, Katashi, Cicogna, Antonio C., Martinez, Paula Felippe |
| المساهمون: | Universidade Estadual Paulista (UNESP) |
| سنة النشر: | 2020 |
| المجموعة: | Universidade Estadual Paulista São Paulo: Repositório Institucional UNESP |
| مصطلحات موضوعية: | Angiotensin II Type 1 Receptor Blockers/ therapeutic use, Cardiovascular Diseases, Diet, High-fat/methods, Losartan/therapeutic use, Obesity, Rats |
| الوصف: | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) ; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; CAPES: 001 ; CNPq: 422776/2016-5 ; Background: Obesity has been associated with chronic activation of the renin-angiotensin-aldosterone system and with significant changes in cardiac performance. Objective: To assess the impact of a blockade of angiotensin-II receptor type 1 (AT1 receptor) on morphology and on myocardial functional performance in rats with high-fat diet-induced obesity. Methods: Wistar rats (n=48) were submitted to control (2.9 kcal/g) or high-fat (3.6 kcal/g) diet for 20 weeks. After the 16th week they were divided into four groups: Control (CO), Obese (OB), Control Losartan (CL) and Obese Losartan (OL). CL and OL received losartan (30 mg/kg/day) in drinking water for four weeks. Subsequently, body composition, systolic blood pressure (SBP) and echocardiographic variables were analyzed. Papillary muscle function was assessed at baseline with 2.50 mM calcium concentration ([Ca2+] ) and after inotropic maneuvers: post-pause potentiation (PPP), [Ca2+]o elevation, and during beta-adrenergic stimulationo with isoproterenol. Analysis of the results was performed by the Two-Way ANOVA and by the appropriate comparison test. The level of significance was set at 5%. Results: Although SBP change had been not maintained at the end of the experiment, obesity was associated with cardiac hypertrophy and with increased left ventricle posterior wall shortening velocity. In the study of papillary muscles in basal condition, CL showed lower developed tension maximum negative variation velocity (-dT/dt) than CO. The 60s PPP promoted lower-dT/dt and maximum developed tension (DT) in OB and CL compared with CO, and higher relative DT variation and maximum positive variation velocity (+dT/dt) in OL compared with CL and OB. Under 1.5, 2.0, and 2.5mM [Ca2+]o, the OL group showed higher-dT/dt than CL. Conclusion: Losartan improves myocardial function in high-fat diet-induced ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 17-28 |
| اللغة: | English Portuguese |
| تدمد: | 1678-4170 0066-782X |
| العلاقة: | Arquivos Brasileiros de Cardiologia; http://dx.doi.org/10.36660/abc.20190131Test; Arquivos Brasileiros de Cardiologia, v. 115, n. 1, p. 17-28, 2020.; http://hdl.handle.net/11449/201155Test; S0066-782X2020000800017; 2-s2.0-85089409957; S0066-782X2020000800017.pdf |
| DOI: | 10.36660/abc.20190131 |
| الإتاحة: | https://doi.org/10.36660/abc.20190131Test http://hdl.handle.net/11449/201155Test |
| حقوق: | openAccess |
| رقم الانضمام: | edsbas.FBE46F63 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16784170 0066782X |
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| DOI: | 10.36660/abc.20190131 |