دورية أكاديمية
Oral fosfomycin for treating lower urinary tract infections due to multidrug-resistant Escherichia coli in female adolescents
| العنوان: | Oral fosfomycin for treating lower urinary tract infections due to multidrug-resistant Escherichia coli in female adolescents |
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| المؤلفون: | Ozkaya-Parlakay, Aslinur, Tapisiz, Anil, Kara, Soner Sertan, Yuksel, Selcuk, Polat, Meltem |
| بيانات النشر: | Taylor & Francis Ltd |
| سنة النشر: | 2022 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | oral, Fosfomycin trometamol, lower urinary tract infections, multidrug-resistant, Escherichia coli, female adolescents, Trometamol, Susceptibility, Outpatient, Netilmicin |
| الوصف: | Fosfomycin trometamol (FT) has shown promising in vitro activity against multidrug-resistant (MDR) uropathogens; however, clinical data are limited in pediatric patients. We conducted a retrospective study to describe the clinical and microbiological outcomes of uncomplicated lower urinary tract infections (LUTIs) due to MDR Escherichia coli treated with oral FT in female adolescents. A total of 70 outpatients, with a median age of 13 years (range 12-16 years), were included. FT was initiated as definitive treatment of UTIs in all patients due to documented resistance against alternative oral agents. All patients received a single dose of 3 g oral FT. The post-treatment clinical and microbiological cure rates were 97% (68/70) and 94% (66/70), respectively. Only two (3%) patients reported mild, self-limited diarrhea. UTI relapse occurred in two (3%) patients. Our results suggest that oral FT might be an alternative option for outpatient treatment of uncomplicated LUTIs due to MDR E. coli in female adolescents. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1973-9478 1120-009X |
| العلاقة: | Journal Of Chemotherapy; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/46447Test; https://doi.org/10.1080/1120009X.2021.1955203Test; 34; 97; 102; 2-s2.0-85111115514; WOS:000675306100001 |
| DOI: | 10.1080/1120009X.2021.1955203 |
| الإتاحة: | https://doi.org/10.1080/1120009X.2021.1955203Test https://hdl.handle.net/11499/46447Test |
| حقوق: | none |
| رقم الانضمام: | edsbas.FBE04147 |
| قاعدة البيانات: | BASE |
| تدمد: | 19739478 1120009X |
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| DOI: | 10.1080/1120009X.2021.1955203 |