كتاب
Sperm DNA fragmentation and male infertility
| العنوان: | Sperm DNA fragmentation and male infertility |
|---|---|
| المؤلفون: | Kandil, Hussein, Farkouh, Ala'A, Saleh, Ramadan, Boitrelle, Florence, Agarwal, Ashok |
| المساهمون: | Fakih IVF Fertility Center, Cleveland Clinic, Sohag University, CHI Poissy-Saint-Germain, Biologie de la Reproduction, Environnement, Epigénétique & Développement (BREED), École nationale vétérinaire d'Alfort (ENVA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| المصدر: | Handbook of Current and Novel Protocols for the Treatment of Infertility ; https://hal.inrae.fr/hal-04304374Test ; Handbook of Current and Novel Protocols for the Treatment of Infertility, Elsevier, pp.29-52, 2024, ⟨10.1016/B978-0-323-85687-4.00018-X⟩ |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2024 |
| المجموعة: | Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| مصطلحات موضوعية: | Male infertility, SDF tests, Semen analysis, Sperm chromatin, Sperm DNA fragmentation, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology |
| الوصف: | International audience ; Numerous studies have shown the detrimental effects of sperm DNA fragmentation (SDF) on reproductive outcomes under both natural and assisted reproduction conditions. SDF testing has evolved as a valuable adjunct in the evaluation of infertile men, and the rapid development of different SDF assays has improved the perception of its clinical utility. However, normal reference ranges of these assays for male fertility potential are still controversial. In this chapter, the pathophysiological aspects of sperm chromatin and the mechanisms behind SDF are discussed. The implications of SDF on various reproductive outcomes are also presented. Additionally, the SDF-induced male infertility, and the possible genetic consequences and birth defects in offspring are highlighted. Furthermore, a comprehensive analysis of the available SDF assays is provided. Finally, we have discussed clinical scenarios on the application of SDF test and the preventive and therapeutic measures to reduce SDF, and lastly, we discussed the future research opportunities. |
| نوع الوثيقة: | book part |
| اللغة: | English |
| العلاقة: | hal-04304374; https://hal.inrae.fr/hal-04304374Test |
| DOI: | 10.1016/B978-0-323-85687-4.00018-X |
| الإتاحة: | https://doi.org/10.1016/B978-0-323-85687-4.00018-XTest https://hal.inrae.fr/hal-04304374Test |
| رقم الانضمام: | edsbas.FBB8CFE8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/B978-0-323-85687-4.00018-X |
|---|