دورية أكاديمية
Quadriceps muscle strength in Duchenne muscular dystrophy and effect of corticosteroid treatment
| العنوان: | Quadriceps muscle strength in Duchenne muscular dystrophy and effect of corticosteroid treatment |
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| المؤلفون: | Luciano Merlini, Ilaria Cecconi, Antonia Parmeggiani, Duccio Maria Cordelli, Ada Dormi |
| المساهمون: | Luciano Merlini, Ilaria Cecconi, Antonia Parmeggiani, Duccio Maria Cordelli, Ada Dormi |
| سنة النشر: | 2020 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | Duchenne muscular dystrophy, quadriceps muscle strength, hand-held dynamometry, corticosteroid treatment, prolongation of walking |
| الوصف: | Objectives. In Duchenne muscular dystrophy, quadriceps weakness is recognized as a key factor in gait deterioration. The objective of this work was three-fold: first, to document the strength of the quadriceps in corticosteroid-naïve DMD boys; second, to measure the effect of corticosteroids on quadriceps strength; and third, to evaluate the correlation between baseline quadriceps strength and the age when starting corticosteroids with the loss of ambulation. Methods. Quadriceps muscle strength using hand-held dynamometry was measured in 12 ambulant DMD boys who had never taken corticosteroids and during corticosteroid treatment until the loss of ambulation. Results. Baseline quadriceps muscle strength at 6 years of age was 28% that of normal children of the same age; it decreased to 15% at 8 years and to 6% at 10 years. The increase in quadriceps muscle strength obtained after 1 year of corticosteroid treatment had a strong direct correlation with the baseline strength (R = 0.96). With corticosteroid treatment, the age of ambulation loss showed a very strong direct relationship (R = 0.92) with baseline quadriceps muscle strength but only a very weak inverse relationship (R = -0.73) with the age of starting treatment. Age of loss of ambulation was 10.3 ± 0.5 vs 19.1 ± 4.7 (P < 0.05) in children with baseline quadriceps muscle strength less than or greater than 40 N, respectively. Conclusions. Corticosteroid-naïve DMD boys have a quantifiable severe progressive quadriceps weakness. This long-term study, for the first time, shows that both of the positive effects obtained with CS treatment, i.e. increasing quadriceps strength and delaying the loss of ambulation, have a strong and direct correlation with baseline quadriceps muscle strength. As such, hand-held dynamometry may be a useful tool in the routine physical examination and during clinical trial assessment. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33458575; volume:39; issue:4; firstpage:200; lastpage:206; numberofpages:7; journal:ACTA MYOLOGICA; https://hdl.handle.net/11585/788723Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85100327698; https://old.actamyologica.it/article/quadriceps-muscle-strength-in-duchenne-muscular-dystrophy-and-effect-of-corticosteroid-treatmentTest/ |
| DOI: | 10.36185/2532-1900-023 |
| الإتاحة: | https://doi.org/10.36185/2532-1900-023Test https://hdl.handle.net/11585/788723Test https://old.actamyologica.it/article/quadriceps-muscle-strength-in-duchenne-muscular-dystrophy-and-effect-of-corticosteroid-treatmentTest/ |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.FBB6DA87 |
| قاعدة البيانات: | BASE |
| DOI: | 10.36185/2532-1900-023 |
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