دورية أكاديمية
Prenatal dietary exposure to mixtures of chemicals is associated with allergy or respiratory diseases in children in the ELFE nationwide cohort
| العنوان: | Prenatal dietary exposure to mixtures of chemicals is associated with allergy or respiratory diseases in children in the ELFE nationwide cohort |
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| المؤلفون: | Ghozal, Manel, Kadawathagedara, Manik, Delvert, Rosalie, Divaret-Chauveau, Amandine, Raherison, Chantal, Varraso, Raphaëlle, Bédard, Annabelle, Crépet, Amélie, Sirot, Véronique, Charles, Marie Aline, Adel-Patient, Karine, de Lauzon-Guillain, Blandine |
| المساهمون: | Research team on early life origins of health, Centre for Research in Epidemiology and Statistics, Conservatoire National des Arts et Métiers CNAM (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers CNAM (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Développement, Adaptation et Handicap. Régulations cardio-respiratoires et de la motricité (DevAH), Université de Lorraine (UL), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté COMUE (UBFC)-Université Bourgogne Franche-Comté COMUE (UBFC), Service d’allergologie pédiatrique CHRU de Nancy, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Cancer environnement (EPICENE ), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Direction de l'Evaluation des Risques (DER), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Institut des Sciences du Vivant Frédéric JOLIOT (JOLIOT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), This study was supported by the Fondation pour la Recherche Médicale (FRM, grant no,: ENV202109013943) and French National Research Institute for Agriculture, Food and Environment (INRAE, including the metaprogram METABIO).The prenatal exposure to food chemicals was estimated within the COCTELL project, supported by the French Agence Nationale de la Recherche (ANR) (grant no.: ANR-14-CE21–0002-02).The ELFE survey is a joint project between the French Institute for Demographic Studies (INED) and the French National Institute of Health and Medical Research (INSERM), in partnership with the French blood transfusion service (Etablissement français du sang, EFS), Santé publique France, the National Institute for Statistics and Economic Studies (INSEE), the Direction générale de la santé (DGS, part of the Ministry of Health and Social Affairs), the Direction générale de la prévention des risques (DGPR, Ministry for the Environment), the Direction de la recherche, des études, de l’évaluation et des statistiques (DREES, Ministry of Health and Social Affairs), the Département des études, de la prospective et des statistiques (DEPS, Ministry of Culture), and the Caisse nationale des allocations familiales (CNAF), with the support of the Ministry of Higher Education and Research and the Institut national de la jeunesse et de l’éducation populaire (INJEP), Via the RECONAI platform, it receives a government grantmanaged by the National Research Agency under the Investissements d’avenir programme (ANR-11-EQPX-0038, ANR-19-COHO-0001)., ANR-14-CE21-0002,COCTELL,Co-exposition intra-utérine et postnatale à un grand nombre de contaminants alimentaires et la croissance et le développement de l'enfant(2014), ANR-11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), ANR-19-COHO-0001,RE-CO-NAI (COHORTES),Resarch platform on cohorts of children followed from birth(2019) |
| المصدر: | ISSN: 1476-069X ; Environmental Health ; https://anses.hal.science/anses-04426377Test ; Environmental Health, 2024, 23 (1), pp.5. ⟨10.1186/s12940-023-01046-y⟩ ; https://ehjournal.biomedcentral.com/articles/10.1186/s12940-023-01046-yTest. |
| بيانات النشر: | HAL CCSD BioMed Central |
| سنة النشر: | 2024 |
| المجموعة: | Université de Lorraine: HAL |
| مصطلحات موضوعية: | Allergy, Birth cohort, Food chemicals, Mixtures, Prenatal exposure, Respiratory diseases, MESH: Female, MESH: Pregnancy, MESH: Eczema, MESH: Furans, MESH: Pesticides, MESH: Polycyclic Aromatic Hydrocarbons, MESH: Food Hypersensitivity, MESH: Fluorocarbons, MESH: Humans, MESH: Child, Preschool, MESH: Dietary Exposure, MESH: Respiratory Sounds, MESH: Trace Elements, MESH: Respiration Disorders, MESH: Respiratory Tract Diseases, MESH: Asthma, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, [SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain |
| الوصف: | International audience ; Introduction Prenatal exposure to environmental chemicals may be associated with allergies later in life. We aimed to examine the association between prenatal dietary exposure to mixtures of chemicals and allergic or respiratory diseases up to age 5.5 y. Methods We included 11,638 mother-child pairs from the French “Étude Longitudinale Française depuis l’Enfance” (ELFE) cohort. Maternal dietary exposure during pregnancy to eight mixtures of chemicals was previously assessed. Allergic and respiratory diseases (eczema, food allergy, wheezing and asthma) were reported by parents between birth and age 5.5 years. Associations were evaluated with adjusted logistic regressions. Results are expressed as odds ratio (OR[95%CI]) for a variation of one SD increase in mixture pattern. Results Maternal dietary exposure to a mixture composed mainly of trace elements, furans and polycyclic aromatic hydrocarbons (PAHs) was positively associated with the risk of eczema (1.10 [1.05; 1.15]), this association was consistent across sensitivity analyses. Dietary exposure to one mixture of pesticides was positively associated with the risk of food allergy (1.10 [1.02; 1.18]), whereas the exposure to another mixture of pesticides was positively but slightly related to the risk of wheezing (1.05 [1.01; 1.08]). This last association was not found in all sensitivity analyses. Dietary exposure to a mixture composed by perfluoroalkyl acids, PAHs and trace elements was negatively associated with the risk of asthma (0.89 [0.80; 0.99]), this association was consistent across sensitivity analyses, except the complete-case analysis. Conclusion Whereas few individual chemicals were related to the risk of allergic and respiratory diseases, some consistent associations were found between prenatal dietary exposure to some mixtures of chemicals and the risk of allergic or respiratory diseases. The positive association between trace elements, furans and PAHs and the risk of eczema, and that between pesticides mixtures and food ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/38195595; anses-04426377; https://anses.hal.science/anses-04426377Test; https://anses.hal.science/anses-04426377/documentTest; https://anses.hal.science/anses-04426377/file/12940_2023_Article_1046.pdfTest; PUBMED: 38195595; PUBMEDCENTRAL: PMC10775451 |
| DOI: | 10.1186/s12940-023-01046-y |
| الإتاحة: | https://doi.org/10.1186/s12940-023-01046-yTest https://anses.hal.science/anses-04426377Test https://anses.hal.science/anses-04426377/documentTest https://anses.hal.science/anses-04426377/file/12940_2023_Article_1046.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.FAF17E15 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12940-023-01046-y |
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