التفاصيل البيبلوغرافية
| العنوان: |
Physical Activity, Genetic Susceptibility, and the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes |
| المؤلفون: |
Hjort, Rebecka, Ahlqvist, Emma, Andersson, Tomas, Alfredsson, Lars, Carlsson, Per-Ola, Grill, Valdemar, Groop, Leif, Martinell, Mats, Sorgjerd, Elin Pettersen, Tuomi, Tiinamaija, Asvold, Bjørn Olav, Carlsson, Sofia |
| المساهمون: |
Centre of Excellence in Complex Disease Genetics, HUS Abdominal Center, Institute for Molecular Medicine Finland, University of Helsinki, Endokrinologian yksikkö, CAMM - Research Program for Clinical and Molecular Metabolism |
| بيانات النشر: |
Endocrine Society |
| سنة النشر: |
2021 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
physical activity, gene-environment interaction, LADA, latent autoimmune diabetes in adults, type 2 diabetes, population-based, NORD-TRONDELAG HEALTH, HUNT, AUTOANTIBODIES, HETEROGENEITY, ASSOCIATION, RELIABILITY, OVERWEIGHT, PREVENTION, VARIANTS, VALIDITY, 3121 General medicine, internal medicine and other clinical medicine |
| الوصف: |
Purpose: Physical activity (PA) has been linked to a reduced risk of type 2 diabetes by reducing weight and improving insulin sensitivity. We investigated whether PA is associated with a lower incidence of latent autoimmune diabetes in adults (LADA) and whether the association is modified by genotypes of human leukocyte antigen (HLA), transcription factor 7-like 2 ( TCF7L2)-rs7903146, or the fat mass and obesity-associated gene, FTO-rs9939609. Methods: We combined data from a Swedish case-control study and a Norwegian prospective study including 621 incident cases of LADA and 3596 cases of type 2 diabetes. We estimated adjusted pooled relative risks (RRs) and 95% CI of diabetes in relation to high (>= 30 minutes of moderate activity 3 times/ week) self-reported leisure time PA, compared to sedentariness. Results: High PA was associated with a reduced risk of LADA (RR 0.61; CI, 0.43-0.86), which was attenuated after adjustment for body mass index (BMI) (RR 0.90; CI, 0.63-1.29). The reduced risk applied only to noncarriers of HLA-DQB1 and -DRB1 (RR 0.49; CI, 0.33-0.72), TCF7L2 (RR 0.62; CI, 0.45-0.87), and FTO (RR 0.51; CI, 0.32-0.79) risk genotypes. Adjustment for BMI attenuated but did not eliminate these associations. For type 2 diabetes, there was an inverse association with PA (RR 0.49; CI, 0.42-0.56), irrespective of genotype. Main Conclusions: Our findings indicate that high PA is associated with a reduced risk of LADA in individuals without genetic susceptibility. ; Peer reviewed |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
ESTRID received funding from the Swedish Research Council (GA 2018-03035), the Swedish Research Council for Health, Working life and Welfare (GA 2018-00337), the Swedish Diabetes Foundation, and the Novo Nordisk Foundation. Funding for EIRA was provided by the Swedish Research Council, the Swedish Research Council for Health, Working Life and Welfare, the Swedish Rheumatic Foundation, the AFA Insurance Company, and Stockholm County Council. Financial support for ANDIS came from the Swedish Research Council and the European Research Council Advanced Researcher grant (GA 269045 to L.G. and A.L.F.-the Swedish Research Council funding for clinical research). The HUNT Study is a collaboration between the HUNT Research Centre (Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology), Nord-Trondelag County Council, Central Norway Regional Health Authority, and the Norwegian Institute of Public Health. GlaxoSmithKline Norway financially supported the diabetes study at HUNT2 and HUNT3 through NTNU. The genotyping in the HUNT Study was financed by the National Institutes of Health (NIH), University of Michigan, The Research Council of Norway, and Central Norway Regional Health Authority and the Faculty of Medicine and Health Sciences, NTNU. The genotype quality control and imputation have been conducted by the K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU.; Hjort , R , Ahlqvist , E , Andersson , T , Alfredsson , L , Carlsson , P-O , Grill , V , Groop , L , Martinell , M , Sorgjerd , E P , Tuomi , T , Asvold , B O & Carlsson , S 2020 , ' Physical Activity, Genetic Susceptibility, and the Risk of Latent Autoimmune Diabetes in Adults and Type 2 Diabetes ' , Journal of Clinical Endocrinology and Metabolism , vol. 105 , no. 11 , 549 . https://doi.org/10.1210/clinem/dgaa549Test; ORCID: /0000-0002-8306-6202/work/86486031; 57d2dc70-ab18-42c9-b00e-87fe409cbac9; http://hdl.handle.net/10138/324057Test; 000584540200031 |
| الإتاحة: |
http://hdl.handle.net/10138/324057Test |
| حقوق: |
cc_by ; openAccess ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.FACD7AD2 |
| قاعدة البيانات: |
BASE |
