دورية أكاديمية
The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients.
| العنوان: | The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients. |
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| المؤلفون: | Ribera, Jordi, Granada, Isabel, Morgades, Mireia, Vives, Susana, Genescà, Eulàlia, González, Celia, Nomdedeu, Josep, Escoda, Lourdes, Montesinos, Pau, Mercadal, Santiago, Coll, Rosa, González-Campos, José, Abella, Eugenia, Barba, Pere, Bermúdez, Arancha, Gil, Cristina, Tormo, Mar, Pedreño, María, Martínez-Carballeira, Daniel, Hernández-Rivas, Jesús-María, Orfao, Alberto, Martínez-López, Joaquín, Esteve, Jordi, Bravo, Pilar, Garcia-Guiñon, Antoni, Debén, Guillermo, Moraleda, José M, Queizán, José A, Ortín, Xavier, Moreno, María J, Feliu, Evarist, Solé, Francesc, Ribera, Josep M, PETHEMA Group, Spanish Society of Haematology |
| سنة النشر: | 2019 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | acute lymphoblastic leukaemia, adults, age, hypodiploidy, prognosis, Adolescent, Adult, Age Factors, Aged, Disease-Free Survival, Female, Humans, Incidence, Male, Middle Aged, Neoplasm, Residual, Ploidies, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Retrospective Studies, Survival Rate |
| الوصف: | The prognostic significance of low-hypodiploidy has not been extensively evaluated in minimal residual disease (MRD)-oriented protocols for adult acute lymphoblastic leukaemia (ALL). We analysed the outcome of hypodiploid adult ALL patients treated within Programa Español de Tratamientos en Hematología (PETHEMA) protocols. The 5-year cumulative incidence of relapse (CIR) of low-hypodiploid B-cell precursor (BCP)-ALL was significantly higher than that of high-hypodiploids (52% vs. 12%, P = 0.013). Low-hypodiploid BCP-ALL patients aged ≤35 years showed superior survival (71% vs. 21%, P = 0.026) and lower 5-year CIR (17% vs. 66%, P = 0.090) than low-hypodiploids aged >35 years. Older adults and elderly low-hypodiploid BCP-ALL patients show dismal prognosis although achieving an end-induction good MRD response. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1365-2141 |
| العلاقة: | http://hdl.handle.net/10668/13761Test |
| DOI: | 10.1111/bjh.15887 |
| الإتاحة: | https://doi.org/10.1111/bjh.15887Test http://hdl.handle.net/10668/13761Test |
| حقوق: | open access |
| رقم الانضمام: | edsbas.FAC8F049 |
| قاعدة البيانات: | BASE |
| تدمد: | 13652141 |
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| DOI: | 10.1111/bjh.15887 |