دورية أكاديمية
On the performance of pre-microRNA detection algorithms
| العنوان: | On the performance of pre-microRNA detection algorithms |
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| المؤلفون: | Saçar Demirci, Müşerref Duygu, Baumbach, Jan, Allmer, Jens |
| المصدر: | Saçar Demirci , M D , Baumbach , J & Allmer , J 2017 , ' On the performance of pre-microRNA detection algorithms ' , Nature Communications , vol. 8 , 330 . https://doi.org/10.1038/s41467-017-00403-zTest |
| سنة النشر: | 2017 |
| المجموعة: | University of Southern Denmark: Research Output / Syddansk Universitet |
| مصطلحات موضوعية: | Algorithms, Computational Biology/methods, Gene Expression Regulation, Humans, Machine Learning, MicroRNAs/genetics, RNA Precursors/genetics, Reproducibility of Results |
| الوصف: | MicroRNAs are crucial for post-transcriptional gene regulation, and their dysregulation has been associated with diseases like cancer and, therefore, their analysis has become popular. The experimental discovery of miRNAs is cumbersome and, thus, many computational tools have been proposed. Here we assess 13 ab initio pre-miRNA detection approaches using all relevant, published, and novel data sets while judging algorithm performance based on ten intrinsic performance measures. We present an extensible framework, izMiR, which allows for the unbiased comparison of existing algorithms, adding new ones, and combining multiple approaches into ensemble methods. In an exhaustive attempt, we condense the results of millions of computations and show that no method is clearly superior; however, we provide a guideline for biomedical researchers to select a tool. Finally, we demonstrate that combining all of the methods into one ensemble approach, for the first time, allows reliable purely computational pre-miRNA detection in large eukaryotic genomes. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://portal.findresearcher.sdu.dk/da/publications/a508d383-ac30-49fa-9e37-5b7140900954Test |
| DOI: | 10.1038/s41467-017-00403-z |
| الإتاحة: | https://doi.org/10.1038/s41467-017-00403-zTest https://portal.findresearcher.sdu.dk/da/publications/a508d383-ac30-49fa-9e37-5b7140900954Test https://findresearcher.sdu.dk/ws/files/135402299/On_the_performance_of_pre_microRNA_detection_algorithms.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.FAC5A614 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-017-00403-z |
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