التفاصيل البيبلوغرافية
| العنوان: |
Wnt Inhibitory Factor 1 Binds to and Inhibits the Activity of Sonic Hedgehog |
| المؤلفون: |
Krisztina Kerekes, Mária Trexler, László Bányai, László Patthy |
| المصدر: |
Cells; Volume 10; Issue 12; Pages: 3496 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2021 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
cancer, cholesterol-group, hedgehog, lipid-group, palmitoyl-group, tumor suppressor, Wnt, Wnt Inhibitory Factor 1 |
| الوصف: |
The hedgehog (Hh) and Wnt pathways, crucial for the embryonic development and stem cell proliferation of Metazoa, have long been known to have similarities that argue for their common evolutionary origin. A surprising additional similarity of the two pathways came with the discovery that WIF1 proteins are involved in the regulation of both the Wnt and Hh pathways. Originally, WIF1 (Wnt Inhibitory Factor 1) was identified as a Wnt antagonist of vertebrates, but subsequent studies have shown that in Drosophila, the WIF1 ortholog serves primarily to control the distribution of Hh. In the present, work we have characterized the interaction of the human WIF1 protein with human sonic hedgehog (Shh) using Surface Plasmon Resonance spectroscopy and reporter assays monitoring the signaling activity of human Shh. Our studies have shown that human WIF1 protein binds human Shh with high affinity and inhibits its signaling activity efficiently. Our observation that the human WIF1 protein is a potent antagonist of human Shh suggests that the known tumor suppressor activity of WIF1 may not be ascribed only to its role as a Wnt inhibitor. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Cell Signaling; https://dx.doi.org/10.3390/cells10123496Test |
| DOI: |
10.3390/cells10123496 |
| الإتاحة: |
https://doi.org/10.3390/cells10123496Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.FABBC5B5 |
| قاعدة البيانات: |
BASE |
