دورية أكاديمية
RhBMP-7 for the Treatment of nonunion of fractures of long bones
| العنوان: | RhBMP-7 for the Treatment of nonunion of fractures of long bones |
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| المؤلفون: | Papanagiotou, M., Dailiana, Z. H., Karachalios, T., Varitimidis, S., Vlychou, M., Hantes, M., Malizos, K. N. |
| المصدر: | Bone and Joint Journal ; http://www.scopus.com/inward/record.url?eid=2-s2.0-84937555551&partnerID=40&md5=523ca70c01138053ebba8db83854fec7Test |
| سنة النشر: | 2015 |
| المجموعة: | University of Thessaly Institutional Repository / Ιδρυματικό Αποθετήριο Πανεπιστημίου Θεσσαλίας |
| مصطلحات موضوعية: | recombinant bone morphogenetic protein, recombinant osteogenic protein 7, unclassified drug, BMP7 protein, human, osteogenic protein 1, adult, aged, Article, bone transplantation, callus, female, fracture nonunion, heterotopic ossification, long bone, long bone nonunion fracture, major clinical study, male, outcome assessment, peroperative complication, postoperative complication, priority journal, quality of life, radiological parameters, recurrent infection, seroma, Short Form 12, treatment response, adolescent, Fractures |
| الوصف: | We report the outcome of 84 nonunions involving long bones which were treated with rhBMP-7, in 84 patients (60 men: 24 women) with a mean age 46 years (18 to 81) between 2003 and 2011. The patients had undergone a mean of three previous operations (one to 11) for nonunion which had been present for a mean of 17 months (4 months to 20 years). The nonunions involved the lower limb in 71 patients and the remainder involved the upper limb. A total of 30 nonunions were septic. Treatment was considered successful when the nonunion healed without additional procedures. The relationship between successful union and the time to union was investigated and various factors including age and gender, the nature of the nonunion (location, size, type, chronicity, previous procedures, infection, the condition of the soft tissues) and type of index procedure (revision of fixation, type of graft, amount of rhBMP-7) were analysed. The improvement of the patients' quality of life was estimated using the Short Form (SF) 12 score. A total of 68 nonunions (80.9%) healed with no need for further procedures at a mean of 5.4 months (3 to 10) post-operatively. Multivariate logistic regression analysis of the factors affecting union suggested that only infection significantly affected the rate of union (p = 0.004).Time to union was only affected by the number of previous failed procedures (p = 0.006). An improvement of 79% and 32.2% in SF-12 physical and mental score, respectively, was noted within the first post-operative year. Rh-BMP-7 combined with bone grafts, enabled healing of the nonunion and improved quality of life in about 80% of patients. Aseptic nonunions were much more likely to unite than septic ones. The number of previous failed operations significantly delayed the time to union. © 2015 The British Editorial Society of Bone & Joint Surgery. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 20494394 |
| العلاقة: | http://hdl.handle.net/11615/31842Test |
| DOI: | 10.1302/0301-620X.97B7.35089 |
| الإتاحة: | https://doi.org/10.1302/0301-620X.97B7.35089Test http://hdl.handle.net/11615/31842Test |
| رقم الانضمام: | edsbas.FA759672 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20494394 |
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| DOI: | 10.1302/0301-620X.97B7.35089 |