التفاصيل البيبلوغرافية
| العنوان: |
Fractions of indels and SNVs in MSH3-deficient adenomas and HGCA. |
| المؤلفون: |
Claudia Perne (8886344), Sophia Peters (4632115), Maria Cartolano (3165243), Sukanya Horpaopan (4632121), Christina Grimm (280266), Janine Altmüller (120887), Anna K. Sommer (11767832), Axel M. Hillmer (10208966), Holger Thiele (455371), Margarete Odenthal (180129), Gabriela Möslein (4504525), Ronja Adam (333161), Sugirthan Sivalingam (3720064), Jutta Kirfel (210681), Michal R. Schweiger (11767835), Martin Peifer (222202), Isabel Spier (4632118), Stefan Aretz (4632109) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Medicine, Cell Biology, Genetics, Molecular Biology, Cancer, Virology, Space Science, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, whole exome sequencing, repetitive sequence context, matched normal tissue, familial adenomatous polyposis, >- related tumourigenesis, >- driven pathway, >- associated polyposis, 21 – 42, early colorectal carcinogenesis, characterise mutational signatures, somatic genetic variation, single nucleotide variants, div >< p, colorectal adenomas caused, candidate driver genes, colorectal adenomas, driver genes, somatic variants, pathogenic somatic |
| الوصف: |
For all somatic variants of the nine MSH3-deficient adenomas including silent variants (952 variants) and for twelve HGCA (2390 variants), the proportions of indels and SNVs were calculated. In MSH3-deficient adenomas, 24% of all variants were indels, which was significantly higher (p < 0.0001) than in HGCA where the proportion of indels was 1.3%. HGCA = high-grade colon adenoma. Indel = insertion/deletion. SNV = Single Nucleotide Variant. |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/figure/Fractions_of_indels_and_SNVs_in_MSH3-deficient_adenomas_and_HGCA_/17094914Test |
| DOI: |
10.1371/journal.pone.0259185.g001 |
| الإتاحة: |
https://doi.org/10.1371/journal.pone.0259185.g001Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.FA628739 |
| قاعدة البيانات: |
BASE |
