التفاصيل البيبلوغرافية
| العنوان: |
3,4‐Methylenedioxymethamphetamine increases interleukin‐1β levels and activates microglia in rat brain: studies on the relationship with acute hyperthermia and 5‐HT depletion |
| المؤلفون: |
Orio, Laura, O'Shea, Esther, Sanchez, Veronica, Pradillo, Jesus M., Escobedo, Isabel, Camarero, Jorge, Moro, Maria A., Green, A. Richard, Colado, M. Isabel |
| المصدر: |
Journal of Neurochemistry ; volume 89, issue 6, page 1445-1453 ; ISSN 0022-3042 1471-4159 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2004 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
3,4‐Methylenedioxymethamphetamine (MDMA) administration to rats produces acute hyperthermia and 5‐HT release. Interleukin‐1β (IL‐1β) is a pro‐inflammatory pyrogen produced by activated microglia in the brain. We examined the effect of a neurotoxic dose of MDMA on IL‐1β concentration and glial activation and their relationship with acute hyperthermia and 5‐HT depletion. MDMA, given to rats housed at 22°C, increased IL‐1β levels in hypothalamus and cortex from 1 to 6 h and [ 3 H]‐(1‐(2‐chlorophenyl)‐ N ‐methyl‐ N ‐(1‐methylpropyl)3‐isoquinolinecarboxamide) binding between 3 and 48 h. Increased immunoreactivity to OX‐42 was also detected. Rats became hyperthermic immediately after MDMA and up to at least 12 h later. The IL‐1 receptor antagonist did not modify MDMA‐induced hyperthermia indicating that IL‐1β release is a consequence, not the cause, of the rise in body temperature. When MDMA was given to rats housed at 4°C, hyperthermia was abolished and the IL‐1β increase significantly reduced. The MDMA‐induced acute 5‐HT depletion was prevented by fluoxetine coadministration but the IL‐1β increase and hyperthermia were unaffected. Therefore, the rise in IL‐1β is not related to the acute 5‐HT release but is linked to the hyperthermia. Contrary to IL‐1β levels, microglial activation is not significantly modified when hyperthermia is prevented, suggesting that it might be a process not dependent on the hyperthermic response induced by MDMA. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/j.1471-4159.2004.02443.x |
| الإتاحة: |
https://doi.org/10.1111/j.1471-4159.2004.02443.xTest |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.FA3FCB35 |
| قاعدة البيانات: |
BASE |
