دورية أكاديمية
Vitamin D Deficiency is Associated With Increased Plasminogen Activator Inhibitor 1/Plasminogen Activator Inhibitor 2 Ratio in Pregnancy
| العنوان: | Vitamin D Deficiency is Associated With Increased Plasminogen Activator Inhibitor 1/Plasminogen Activator Inhibitor 2 Ratio in Pregnancy |
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| المؤلفون: | Andersen, Matilde Kanstrup, Rüdiger, Isabella Hangaard, Vestergaard, Anna Louise, Palarasah, Yaseelan, Bor, Pinar, Larsen, Agnete, Bor, Mustafa Vakur |
| المصدر: | Andersen , M K , Rüdiger , I H , Vestergaard , A L , Palarasah , Y , Bor , P , Larsen , A & Bor , M V 2023 , ' Vitamin D Deficiency is Associated With Increased Plasminogen Activator Inhibitor 1/Plasminogen Activator Inhibitor 2 Ratio in Pregnancy ' , Clinical and Applied Thrombosis/Hemostasis , vol. 29 . https://doi.org/10.1177/10760296231201855Test |
| سنة النشر: | 2023 |
| المجموعة: | Aarhus University: Research |
| مصطلحات موضوعية: | blood coagulation, hemostasis, plasminogen activator inhibitor 1, plasminogen activator inhibitor 2, pregnancy, vitamin d |
| الوصف: | Background: Vitamin D deficiency has recently been suggested as an independent risk factor for thrombosis. Notably, vitamin D deficiency is common in pregnant populations, whom already have an increased thrombotic risk. However, pregnant women are commonly excluded from studies investigating the hemostatic system, and knowledge on the impact of vitamin D on hemostasis in pregnancy is therefore limited. Methods: A cross-sectional study comparing the hemostatic profile of pregnant women (gestational week 12.9 ± 0.7) with vitamin D deficiency (≤50 nmol/L) (n = 70) and high adequate vitamin D status (≥100 nmol/L) (n = 59). Results: Vitamin D deficient women displayed increased plasminogen activator inhibitor 1 levels and an increased plasminogen activator inhibitor 1/plasminogen activator inhibitor 2 ratio, even after adjusting for factors with potential influence on hemostasis (body mass index, smoking and use of fish oil supplements). Conclusions: Vitamin D deficiency is associated with increased plasminogen activator inhibitor 1/plasminogen activator inhibitor 2 ratio in pregnant women. As an increased plasminogen activator inhibitor 1/plasminogen activator inhibitor 2 ratio with high plasminogen activator inhibitor 1 levels may increase thrombotic risk and is associated with the development of pregnancy complications, further research is needed to determine the optimal vitamin D supplementation in pregnancy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://pure.au.dk/portal/en/publications/491807ff-d5b8-4018-9162-562718eccf06Test |
| DOI: | 10.1177/10760296231201855 |
| الإتاحة: | https://doi.org/10.1177/10760296231201855Test https://pure.au.dk/portal/en/publications/491807ff-d5b8-4018-9162-562718eccf06Test http://www.scopus.com/inward/record.url?scp=85171697224&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.FA082305 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/10760296231201855 |
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