التفاصيل البيبلوغرافية
| العنوان: |
Novel Metabolic Regulation of Bile Acid Responses to Low Cholesterol in Whole-Grain-Diet-Fed Mice |
| المؤلفون: |
Jinxin Liu (311455), Yu Wang (12152), Lamei Xue (6717716), Chenzhipeng Nie (7861862), Juan Sun (439334), Mingcong Fan (6717719), Haifeng Qian (179918), Li Wang (15202), Yan Li (23143) |
| سنة النشر: |
1753 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Genetics, Molecular Biology, Physiology, Ecology, Science Policy, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Novel Metabolic Regulation, scavenger receptor class B type, bile acid homeostasis, HMGCR, bile acid excretion, bile acid metabolism, bile acid reabsorption, whole-grain diets, 3- hydroxy -3-methylglutaryl reductase, Whole-Grain-Diet-Fed Mice Hyperchol., ABCG, feed conversion ratio, ATP, LDLR, polypeptide 1, SR-BI, CYP, bile acid synthesis, TG, TC |
| الوصف: |
Hypercholesterolemia is a major risk factor for chronic metabolic diseases. Nevertheless, a whole-grain diet could ameliorate this issue in a number of ways, including by regulating bile acid metabolism. However, the potential mechanism is unclear. The aim of the current study is to explore the effects of whole-grain diets (brown rice diet and whole wheat diet) on bile acid homeostasis. After intervention for 8 weeks in mouse model, whole-grain diets showed reduced feed conversion ratio, and the lipid levels (total cholesterol (TC) and triglycerides (TG)) were also meliorated in the serum and liver of mice. Moreover, whole-grain diets reduced the expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) (cholesterol synthesis) in the liver of mice. Interestingly, whole-grain diets not only promoted the mRNA expressions of low-density lipoprotein receptor (LDLR), ATP binding cassette transporter G1 (ABCG1), and scavenger receptor class B type I (SR-BI) (reverse cholesterol transport) but also facilitated the expressions of cytochrome P450, family 7, subfamily a, polypeptide 1 (CYP7a1) and cytochrome P450, family 27, subfamily a, polypeptide 1 (CYP27a1) (bile acid synthesis). Further study found that whole-grain diets promoted intestinal bile acid reabsorption and reduced bile acid excretion. Our study provided a novel metabolic regulation of bile acids in response to reduced cholesterol levels induced by whole-grain diets. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Novel_Metabolic_Regulation_of_Bile_Acid_Responses_to_Low_Cholesterol_in_Whole-Grain-Diet-Fed_Mice/15028481Test |
| DOI: |
10.1021/acs.jafc.1c02662.s001 |
| الإتاحة: |
https://doi.org/10.1021/acs.jafc.1c02662.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.F98BC42C |
| قاعدة البيانات: |
BASE |
