التفاصيل البيبلوغرافية
| العنوان: |
Methemoglobinemia-A biomarker and a link to ferric iron accumulation in Alzheimer's disease |
| المؤلفون: |
Lucijan Mohorovic, Anna M Lavezzi, Sanja Stifter, George Perry, Djulija Malatestinic, Vladimir Micovic, Eris Materljan, Herman Haller, Oleg Petrovic |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
http://users2.unimi.it/centrolinorossi/files/pub/methemoglobinemia_2014.pdfTest. |
| سنة النشر: |
2014 |
| المجموعة: |
CiteSeerX |
| الوصف: |
Understanding the mechanism of oxidative stress is likely to yield new insights regarding the pathogenesis of Alzheimer's disease (AD). Our earlier work focused on the difference between hemoglobin and methemoglobin degradation, respectively leading to ferrous (Fe 2+ ) iron, or ferric (Fe 3+ ) iron. Methemoglobin has the role of carrier, the donor of cytotoxic and redox-active ferric (Fe 3+ ) iron, which can directly accumulate and increase the rate of capillary endothelial cell apoptosis, and may cross into the brain parenchyma, to the astrocytes, glia, neurons, and other neuronal cells (neurovascular unit). This supposition helps us to understand the transport and neuronal accumulation process of ferric iron, and determine how iron is transported and accumulated intracellularly, identifiable as "Brain rust". Earlier research found that the incidences of neonatal jaundice (p = 0.034), heart murmur (p = 0.011) and disorders such as dyslalia and learning/memory impairments (p = 0.002) were significantly higher in those children born from mothers with methemoglobinemia. Our hypothesis suggests that prenatal iron abnormalities could lead to greater neuronal death, the disease ageing process, and neurodegenerative disorders such as AD and other neurodegenerative diseases. KEYWORDS |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1090.4499Test; http://users2.unimi.it/centrolinorossi/files/pub/methemoglobinemia_2014.pdfTest |
| الإتاحة: |
http://users2.unimi.it/centrolinorossi/files/pub/methemoglobinemia_2014.pdfTest |
| حقوق: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.F987FB7A |
| قاعدة البيانات: |
BASE |
