دورية أكاديمية
Lithium halide filled carbon nanocapsules: Paving the way towards lithium neutron capture therapy (LiNCT)
| العنوان: | Lithium halide filled carbon nanocapsules: Paving the way towards lithium neutron capture therapy (LiNCT) |
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| المؤلفون: | Gonçalves, Gil, Sandoval, Stefania, Llenas, Marina, Ballesteros, Belén, Da Ros, Tatiana, Bortolussi, Silva, Cansolino, Laura, Ferrari, Cinzia, Postuma, Ian, Protti, Nicoletta, Melle Franco, Manuel, Altieri, Saverio, Tobias, Gerard |
| المساهمون: | European Research Council, Fundação para a Ciência e a Tecnologia (Portugal), European Commission, Istituto Nazionale di Fisica Nucleare, Agencia Estatal de Investigación (España), Generalitat de Catalunya, Gonçalves, Gil, Sandoval, Stefania, Llenas, Marina, Ballesteros, Belén, Da Ros, Tatiana, Bortolussi, Silva, Cansolino, Laura, Ferrari, Cinzia, Postuma, Ian, Protti, Nicoletta, Altieri, Saverio, Tobias, Gerard |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | 6Li, Cancer, Carbon nanohorns, Enriched lithium, Lithium-6, Nanooncology, Radiotherapy, Short multiwall carbon nanotubes |
| الوصف: | Neutron capture therapy (NCT) is a form of radiotherapy that exploits the potential of some specific isotopes to capture thermal neutrons and subsequently yield high linear energy transfer (LET) particles, suitable for cancer treatment. Recently, relevant technological improvements have been made in terms of accelerators as suitable neutron sources for NCT at hospitals. However, low selective delivery of current drugs to cancer cells remains as the main challenge for successful clinical application of NCT. This work presents an innovative and previously unexplored approach for the design of nanotherapeutic NCT agents. Herein, a new concept based on carbon nanomaterials that seal 6Li active NCT nuclides is investigated. The 6Li active species are located in the inner cavity of the nanocarrier (carbon nanohorns or carbon nanotubes) and therefore, completely protected from the biological environment, avoiding toxicity and degradation. After encapsulation of the active cargo, the external surface of the nanocarrier is modified for improved biocompatibility. The developed 6Li-filled carbon nanohorns offered the possibility to explore 6Li compounds as active NCT agents by delivering therapeutic doses to cancer cells. We envisage that nanoencapsulation of 6Li can trigger the successful development and implementation of Lithium Neutron Cancer Therapy (LiNCT). ; G. T. acknowledges funding from ERC Consolidator Grant NEST (725743). G.G. gratefully acknowledges the funding by the Portuguese Science Foundation (FCT) for Programme Stimulus of Scientific Employment – Individual Support (CEECIND/01913/2017), financial support of project CARBONCT (2022.03596.PTDC), TEMA UIDB/00481/2020 and UIDP/00481/2020; and CENTRO-01-0145-FEDER-022083 - Centro Portugal Regional Operational Programme (Centro2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund. In addition, support through the project IF/00894/2015 and within the scope of the project CICECO-Aveiro Institute of Materials, ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0008-6223 |
| العلاقة: | #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/AEI/Plan Estatal de investigación Científica y Técnica y de Innovación 2017-2020/CEX2019-000917-S; info:eu-repo/grantAgreement/AEI/Plan Estatal de investigación Científica y Técnica y de Innovación 2021-2023/CEX2021-001214-S; Carbon; Publisher's version; http://doi.org/10.1016/j.carbon.2023.03.034Test; Sí; Carbon 208: 148-159 (2023); http://hdl.handle.net/10261/331364Test; http://dx.doi.org/10.13039/501100011033Test; http://dx.doi.org/10.13039/501100000780Test; http://dx.doi.org/10.13039/501100000781Test; http://dx.doi.org/10.13039/501100001871Test; http://dx.doi.org/10.13039/501100002809Test; 2-s2.0-85151471852; https://api.elsevier.com/content/abstract/scopus_id/85151471852Test |
| DOI: | 10.1016/j.carbon.2023.03.034 |
| DOI: | 10.13039/501100011033 |
| DOI: | 10.13039/501100000780 |
| DOI: | 10.13039/501100000781 |
| DOI: | 10.13039/501100001871 |
| DOI: | 10.13039/501100002809 |
| الإتاحة: | https://doi.org/10.1016/j.carbon.2023.03.03410.13039/50110001103310.13039/50110000078010.13039/50110000078110.13039/50110000187110.13039/501100002809Test http://hdl.handle.net/10261/331364Test https://api.elsevier.com/content/abstract/scopus_id/85151471852Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.F9810E03 |
| قاعدة البيانات: | BASE |
| تدمد: | 00086223 |
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| DOI: | 10.1016/j.carbon.2023.03.034 |