دورية أكاديمية
Cumulative Systolic Blood Pressure and Incident Stroke Type Variation by Race and Ethnicity
| العنوان: | Cumulative Systolic Blood Pressure and Incident Stroke Type Variation by Race and Ethnicity |
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| المؤلفون: | Johnson, Kimson E., Li, Hanyu, Zhang, Min, Springer, Mellanie V., Galecki, Andrzej T., Whitney, Rachael T., Gottesman, Rebecca F., Hayward, Rodney A., Sidney, Stephen, Elkind, Mitchell S. V., Longstreth, W. T., Heckbert, Susan R., Gerber, Yariv, Sullivan, Kevin J., Levine, Deborah A. |
| المصدر: | JAMA Network Open ; volume 7, issue 5, page e248502 ; ISSN 2574-3805 |
| بيانات النشر: | American Medical Association (AMA) |
| سنة النشر: | 2024 |
| الوصف: | Importance Stroke risk varies by systolic blood pressure (SBP), race, and ethnicity. The association between cumulative mean SBP and incident stroke type is unclear, and whether this association differs by race and ethnicity remains unknown. Objective To examine the association between cumulative mean SBP and first incident stroke among 3 major stroke types—ischemic stroke (IS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH)—and explore how these associations vary by race and ethnicity. Design, Setting, and Participants Individual participant data from 6 US longitudinal cohorts (January 1, 1971, to December 31, 2019) were pooled. The analysis was performed from January 1, 2022, to January 2, 2024. The median follow-up was 21.6 (IQR, 13.6-31.8) years. Exposure Time-dependent cumulative mean SBP. Main Outcomes and Measures The primary outcome was time from baseline visit to first incident stroke. Secondary outcomes consisted of time to first incident IS, ICH, and SAH. Results Among 40 016 participants, 38 167 who were 18 years or older at baseline with no history of stroke and at least 1 SBP measurement before the first incident stroke were included in the analysis. Of these, 54.0% were women; 25.0% were Black, 8.9% were Hispanic of any race, and 66.2% were White. The mean (SD) age at baseline was 53.4 (17.0) years and the mean (SD) SBP at baseline was 136.9 (20.4) mm Hg. A 10–mm Hg higher cumulative mean SBP was associated with a higher risk of overall stroke (hazard ratio [HR], 1.20 [95% CI, 1.18-1.23]), IS (HR, 1.20 [95% CI, 1.17-1.22]), and ICH (HR, 1.31 [95% CI, 1.25-1.38]) but not SAH (HR, 1.13 [95% CI, 0.99-1.29]; P = .06). Compared with White participants, Black participants had a higher risk of IS (HR, 1.20 [95% CI, 1.09-1.33]) and ICH (HR, 1.67 [95% CI, 1.30-2.13]) and Hispanic participants of any race had a higher risk of SAH (HR, 3.81 [95% CI, 1.29-11.22]). There was no consistent evidence that race and ethnicity modified the association of cumulative mean SBP with first incident ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1001/jamanetworkopen.2024.8502 |
| الإتاحة: | https://doi.org/10.1001/jamanetworkopen.2024.8502Test https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2818247/johnson_2024_oi_240311_1713978026.97395.pdfTest |
| رقم الانضمام: | edsbas.F942DF09 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1001/jamanetworkopen.2024.8502 |
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