دورية أكاديمية
Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients
| العنوان: | Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients |
|---|---|
| المؤلفون: | Fourdinier, Ophélie, Schepers, Eva, Metzinger-Le Meuth, Valérie, Glorieux, Griet, Liabeuf, Sophie, Verbeke, Francis, Vanholder, Raymond, Brigant, Benjamin, Pletinck, Anneleen, Diouf, Momar, Burtey, Stéphane, Choukroun, Gabriel, Massy, Ziad A., Metzinger, Laurent |
| المساهمون: | INSERM U-1088, Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, Ghent University Hospital, Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Universitaire Ambroise Paré (CHU Ambroise Paré) |
| المصدر: | ISSN: 2045-2322. |
| بيانات النشر: | HAL CCSD Nature Publishing Group |
| سنة النشر: | 2019 |
| المجموعة: | Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| مصطلحات موضوعية: | [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience ; Several microRNAs (miRNAs) have been linked to chronic kidney disease (CKD) mortality, cardiovascular (CV) complications and kidney disease progression. However, their association with clinical outcomes remains poorly evaluated. We used real-time qPCR to measure serum levels of miR-126 and miR-223 in a large cohort of 601 CKD patients (CKD stage G1 to G5 patients or on renal replacement therapy – CKD G5D) from Ghent University Hospital and 31 healthy controls. All-cause mortality and cardiovascular and renal events were registered as endpoints over a 6 year follow-up period. miR-126 levels were significantly lower from CKD stage G2 on, compared to controls. The serum levels of miR-223 were significantly lower from CKD stage G3B on. When considering overall mortality, patients with levels of either miR-126 or miR-223 below the median had a lower survival rate. Similar results were observed for CV and renal events. The observed link between the two miRNAs’ seric levels and mortality, cardiovascular events or renal events in CKD appears to depend on eGFR. However, this does not preclude their potential role in the pathophysiology of CKD. In conclusion, CKD is associated with a decrease in circulating miR-223 and miR-126 levels |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-02625556; https://hal.inrae.fr/hal-02625556Test; https://hal.inrae.fr/hal-02625556/documentTest; https://hal.inrae.fr/hal-02625556/file/2019_Fourdinier_ScientificReports_1.pdfTest; PRODINRA: 476212; WOS: 000461151800061 |
| DOI: | 10.1038/s41598-019-41101-8 |
| الإتاحة: | https://doi.org/10.1038/s41598-019-41101-8Test https://hal.inrae.fr/hal-02625556Test https://hal.inrae.fr/hal-02625556/documentTest https://hal.inrae.fr/hal-02625556/file/2019_Fourdinier_ScientificReports_1.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.F93EF20D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-019-41101-8 |
|---|