دورية أكاديمية
Workshop report : Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology ; Liver Toxicity Mode-of-Action
| العنوان: | Workshop report : Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology ; Liver Toxicity Mode-of-Action |
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| المؤلفون: | Willet, Catherine, Caverly Rea, Jessica, Goyak, Katy O., Minsavage, Gary, Westmoreland, Carl, Andersen, Melvin, Avigan, Mark, Duché, Daniel, Harris, Georgina, Hartung, Thomas, Jaeschke, Hartmut, Kleensang, Andre, Landesmann, Brigitte, Martos, Suzanne, Matevia, Marilyn, Toole, Colleen, Rowan, Andrew, Schultz, Terry, Seed, Jennifer, Senior, John, Shah, Imran, Subramanian, Kalyanasundaram, Vinken, Mathieu, Watkins, Paul |
| المصدر: | Alternatives to Animal Experimentation : ALTEX. 2014, 31(4), pp. 500-519. ISSN 1868-596X. eISSN 1868-8551. Available under: doi:10.14573/altex.1401281 |
| سنة النشر: | 2014 |
| المجموعة: | University of Konstanz: Konstanz Online Publication Server (KOPS) |
| مصطلحات موضوعية: | systems toxicology, pathways of toxicity, adverse outcome pathways, in vitro toxicology, liver toxicity, ddc:570 |
| الوصف: | A workshop sponsored by the Human Toxicology Project Consortium (HTPC), “Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action” brought together experts from a wide range of perspectives to inform the process of pathway development and to advance two prototype pathways initially developed by the European Commission Joint Research Center (JRC): liver-specific fibrosis and steatosis. The first half of the workshop focused on the theory and practice of pathway development; the second on liver disease and the two prototype pathways. Participants agreed pathway development is extremely useful for organizing information and found that focusing the theoretical discussion on a specific AOP is helpful. It is important to include several perspectives during pathway development, including information specialists, pathologists, human health and environmental risk assessors, and chemical and product manufacturers, to ensure the biology is well captured and end use is considered. ; published ; published |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://nbn-resolving.de/urn:nbn:de:bsz:352-0-268752Test; http://dx.doi.org/10.14573/altex.1401281Test; 428598110 |
| DOI: | 10.14573/altex.1401281 |
| الإتاحة: | https://doi.org/10.14573/altex.1401281Test http://nbn-resolving.de/urn:nbn:de:bsz:352-0-268752Test |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.F8E23BFD |
| قاعدة البيانات: | BASE |
| DOI: | 10.14573/altex.1401281 |
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