دورية أكاديمية
Cognitive phenotypes in Alzheimer's disease and genetic variants in ACE and IDE
| العنوان: | Cognitive phenotypes in Alzheimer's disease and genetic variants in ACE and IDE |
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| المؤلفون: | Vardy, Emma R L C, Brown, Kristelle, Stopford, Cheryl L, Thompson, Jennifer C, Richardson, Anna M, Neary, David, Kalsheker, Noor, Morgan, Kevin, Mann, David M, Snowden, Julie S |
| المصدر: | Vardy , E R L C , Brown , K , Stopford , C L , Thompson , J C , Richardson , A M , Neary , D , Kalsheker , N , Morgan , K , Mann , D M & Snowden , J S 2012 , ' Cognitive phenotypes in Alzheimer's disease and genetic variants in ACE and IDE ' , Neurobiology of Aging , vol. 33 , no. 7 , pp. 1486.e1-1486.e2 . https://doi.org/10.1016/j.neurobiolaging.2010.11.003Test , https://doi.org/10.1016/j.neurobiolaging.2010.11.003Test |
| سنة النشر: | 2012 |
| المجموعة: | The University of Manchester: Research Explorer - Publications |
| مصطلحات موضوعية: | Alzheimer Disease/diagnosis, Cognition Disorders/diagnosis, Female, Genetic Predisposition to Disease/genetics, Genetic Variation/genetics, Humans, Insulysin/genetics, Male, Peptidyl-Dipeptidase A/genetics, Phenotype |
| الوصف: | Alzheimer's disease (AD) is generally considered to be a disorder primarily affecting memory. It is increasingly recognized that the clinical presentation or "cognitive phenotype" is variable. The apolipoprotein E ε4 (APOE ε4) allele has been associated with an amnestic presentation, but does not appear to fully explain the high prevalence of family history within this group. We examined polymorphisms in the genes ACE and IDE in relation to cognitive phenotype. In this study 276 participants with AD were categorized into 1 of 4 cognitive phenotype classifications: typical, amnestic, language, and posterior. Family history and possession of the APOE ε4 allele were most prevalent in the amnestic group. Of the 10 genetic variants of IDE, and the 3 genetic variants of ACE studied, only ACErs4291 and ACErs1800764 were nominally associated with the amnestic presentation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1016/j.neurobiolaging.2010.11.003 |
| الإتاحة: | https://doi.org/10.1016/j.neurobiolaging.2010.11.003Test https://research.manchester.ac.uk/en/publications/6fb64a9d-4563-452a-a29f-abbe2f77c511Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.F85449E6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.neurobiolaging.2010.11.003 |
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