التفاصيل البيبلوغرافية
| العنوان: |
Involvement of apoptosis in patients with diabetic nephropathy: A study on plasma soluble Fas levels and pathological findings |
| المؤلفون: |
BABA, KAORI, MINATOGUCHI, SHINYA, SANO, HIROTAKE, KAGAWA, TOMOYO, MURATA, ICHIJIRO, TAKEMURA, GENZOU, HIRANO, TAKAHIRO, OHASHI, HIROSHIGE, TAKEMURA, MASAO, FUJIWARA, TAKAKO, FUJIWARA, HISAYOSHI |
| المصدر: |
Nephrology ; volume 9, issue 2, page 94-99 ; ISSN 1320-5358 1440-1797 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2004 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
SUMMARY: Aims: We investigated the relationship between levels of plasma soluble Fas (sFas) and stages of diabetic nephropathy, with special reference to apoptosis and clinical features of diabetic nephropathy in 168 patients with diabetic nephropathy. Results: There was a positive correlation between plasma sFas and creatinine levels, between sFas levels and urinary protein levels, and between sFas levels and urinary albumin. There was a negative correlation between plasma sFas levels and creatinine clearance. Plasma sFas levels in the early stage (stages 1, 2, 3A) and advanced stage (stages 3B and 4) were 2.6 ± 0.1 and 5.4 ± 0.5 ng/mL, respectively. Plasma sFas level of the advanced stage was significantly higher than that of the early stage. The number of proliferating cell nuclear antigen (PCNA) positive cells was significantly lower in the advanced stage than in the early stage. The number of in situ nick‐end labelling (TUNEL) positive cells was also significantly lower in the advanced stage than in the early stage, suggesting the suppression of apoptosis. Conclusion: These data suggest that apoptosis is involved in the advancement of diabetic nephropathy, and that plasma sFas level might be a predicting factor for prognosis. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/j.1440-1797.2004.00238.x |
| الإتاحة: |
https://doi.org/10.1111/j.1440-1797.2004.00238.xTest |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.F82FFC58 |
| قاعدة البيانات: |
BASE |
