دورية أكاديمية
The WATCH-DM risk score estimates clinical outcomes in type 2 diabetic patients with heart failure with preserved ejection fraction
| العنوان: | The WATCH-DM risk score estimates clinical outcomes in type 2 diabetic patients with heart failure with preserved ejection fraction |
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| المؤلفون: | Iwakura, Katsuomi, Onishi, Toshinari, Okamura, Atsunori, Koyama, Yasushi, Tanaka, Nobuaki, Okada, Masato, Fujii, Kenshi, Seo, Masahiro, Yamada, Takahisa, Yano, Masamichi, Hayashi, Takaharu, Yasumura, Yoshio, Nakagawa, Yusuke, Tamaki, Shunsuke, Nakagawa, Akito, Sotomi, Yohei, Hikoso, Shungo, Nakatani, Daisaku, Sakata, Yasushi, Watanabe, Tetsuya, Higuchi, Yoshiharu, Masuda, Masaharu, Asai, Mitsutoshi, Mano, Toshiaki, Fuji, Hisakazu, Masuda, Daisaku, Shutta, Ryu, Yamashita, Shizuya, Sairyo, Masami, Abe, Haruhiko, Ueda, Yasunori, Matsumura, Yasushi, Nagai, Kunihiko, Nishino, Masami, Tanouchi, Jun, Arita, Yoh, Ogasawara, Nobuyuki, Ishizu, Takamaru, Ichikawa, Minoru, Takano, Yuzuru, Rin, Eisai, Shinoda, Yukinori, Tachibana, Koichi, Hoshida, Shiro, Izumi, Masahiro, Yamamoto, Hiroyoshi, Kato, Hiroyasu, Nakatani, Kazuhiro, Yasuga, Yuji, Nishio, Mayu |
| المساهمون: | Roche Diagnostics, FUJIFILM Toyama Chemical |
| المصدر: | Scientific Reports ; volume 14, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Multidisciplinary |
| الوصف: | The coexistence of heart failure is frequent and associated with higher mortality in patients with type 2 diabetes (T2DM), and its management is a critical issue. The WATCH-DM risk score is a tool to predict heart failure in patients with type 2 diabetes mellitus (T2DM). We investigated whether it could estimate outcomes in T2DM patients with heart failure with preserved ejection fraction (HFpEF). The WATCH-DM risk score was calculated in 418 patients with T2DM hospitalized for HFpEF (male 49.5%, age 80 ± 9 years, HbA1c 6.8 ± 1.0%), and they were divided into the “average or lower” (≤ 10 points), “high” (11–13 points) and “very high” (≥ 14 points) risk groups. We followed patients to observe all-cause death for 386 days (median). We compared the area under the curve (AUC) of the WATCH-DM score for predicting 1-year mortality with that of the Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) score and of the Barcelona Bio-Heart Failure Risk (BCN Bio-HF). Among the study patients, 108 patients (25.8%) had average or lower risk scores, 147 patients (35.2%) had high risk scores, and 163 patients (39.0%) had very high risk scores. The Cox proportional hazard model selected the WATCH-DM score as an independent predictor of all-cause death (HR per unit 1.10, 95% CI 1.03 to 1.19), and the “average or lower” risk group had lower mortality than the other groups (p = 0.047 by log-rank test). The AUC of the WATCH-DM for 1-year mortality was 0.64 (95% CI 0.45 to 0.74), which was not different from that of the MAGGIC score (0.72, 95% CI 0.63 to 0.80, p = 0.08) or that of BCN Bio-HF (0.70, 0.61 to 0.80, p = 0.25). The WATCH-DM risk score can estimate prognosis in T2DM patients with HFpEF and can identify patients at higher risk of mortality. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-024-52101-8 |
| الإتاحة: | https://doi.org/10.1038/s41598-024-52101-8Test https://www.nature.com/articles/s41598-024-52101-8.pdfTest https://www.nature.com/articles/s41598-024-52101-8Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.F7BF02A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-024-52101-8 |
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