دورية أكاديمية
Intensive Structured Self-Monitoring of Blood Glucose and Glycemic Control in Noninsulin-Treated Type 2 Diabetes: The PRISMA Randomized Trial
| العنوان: | Intensive Structured Self-Monitoring of Blood Glucose and Glycemic Control in Noninsulin-Treated Type 2 Diabetes: The PRISMA Randomized Trial |
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| المؤلفون: | Bosi E, Scavini M, Ceriello A, Cucinotta D, Tiengo A, Marino R, Bonizzoni E, Giorgino F, on behalf of the PRISMA Study Group, Trevisan R, Dodesini AR, Corsi A, Sciangula L, Ciucci A, Olivo ES, Tonutti L, Boscariol C, Armellini M, Pozzilli P, Maurizi AR, Manfrini S, Napoli N, Tuccinardi D, Ghirlanda G, Gagliardi L, Ranalli L, Zaccuri S, Giorgianni L, Guarnieri G, Di Bartolo P, Pellicano F, Scolozzi P, Leotta S, Fontana L, Tonolo G, Cherchi S, Canu L, Foglini P, Maricotti R, Tortato E, Pianti C, Madaschi S, Tortul C, Da Ros R, Muraro R, Ansaldi E, Cacciola S, Cignarelli M, Lamacchia O, Nizzoli M, Buci L, Calatola P, Clemente G, Caputo A, Mollo F, Friogato G, Rampini A, Morpurgo P, Bonino G, Vita MG, Laviola L, Gnasso A, Carallo C, Calabria M, Beltramello G, Marangoni A, Cattaneo A, Guido R, Massidda A, Meloni G, Bonomo MA, Pizzi G, Camerini M, Provenzano V, Ferrara L, Provenzano F, Paccagnella A, Sambataro M, Almoto B, Baroni MG, Cossu E, Zedde A, Consoli A, Di Fulvio P, DOTTA, FRANCESCO, Guarino E, Annuzzi G, Bozzeto L, Cicioni G, Calabrese M, Guizzotti S, Cabasino F, Farci F, Ghiani M, Tubili C, Nardone MR, Candido R, Tommasi E, Jagodnik G, Strazzabosco M, Mesturino CA, Santeusanio F, Torlone E, Annone S. |
| المساهمون: | Bosi, E, Scavini, M, Ceriello, A, Cucinotta, D, Tiengo, A, Marino, R, Bonizzoni, E, Giorgino, F, on behalf of the PRISMA Study, Group, Trevisan, R, Dodesini, Ar, Corsi, A, Sciangula, L, Ciucci, A, Olivo, E, Tonutti, L, Boscariol, C, Armellini, M, Pozzilli, P, Maurizi, Ar, Manfrini, S, Napoli, N, Tuccinardi, D, Ghirlanda, G, Gagliardi, L, Ranalli, L, Zaccuri, S, Giorgianni, L, Guarnieri, G, Di Bartolo, P, Pellicano, F, Scolozzi, P, Leotta, S, Fontana, L, Tonolo, G, Cherchi, S, Canu, L, Foglini, P, Maricotti, R, Tortato, E, Pianti, C, Madaschi, S, Tortul, C, Da Ros, R, Muraro, R, Ansaldi, E, Cacciola, S, Cignarelli, M, Lamacchia, O, Nizzoli, M, Buci, L, Calatola, P, Clemente, G, Caputo, A, Mollo, F, Friogato, G, Rampini, A, Morpurgo, P, Bonino, G, Vita, Mg, Laviola, L, Gnasso, A, Carallo, C, Calabria, M, Beltramello, G, Marangoni, A, Cattaneo, A, Guido, R, Massidda, A, Meloni, G, Bonomo, Ma, Pizzi, G, Camerini, M, Provenzano, V, Ferrara, L, Provenzano, F, Paccagnella, A, Sambataro, M, Almoto, B, Baroni, Mg, Cossu, E, Zedde, A, Consoli, A, Di Fulvio, P, Dotta, Francesco, Guarino, E, Annuzzi, G, Bozzeto, L, Cicioni, G, Calabrese, M, Guizzotti, S, Cabasino, F, Farci, F, Ghiani, M, Tubili, C, Nardone, Mr |
| سنة النشر: | 2013 |
| المجموعة: | Università degli Studi di Siena: USiena air |
| الوصف: | OBJECTIVE: We aimed to evaluate the added value of intensive self-monitoring of blood glucose (SMBG), structured in timing and frequency, in noninsulin-treated patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: The 12-month, randomized, clinical trial enrolled 1,024 patients with noninsulin-treated type 2 diabetes (median baseline HbA1c, 7.3% [IQR, 6.9-7.8%]) at 39 diabetes clinics in Italy. After standardized education, 501 patients were randomized to intensive structured monitoring (ISM) with 4-point glycemic profiles (fasting, preprandial, 2-h postprandial, and postabsorptive measurements) performed 3 days/week; 523 patients were randomized to active control (AC) with 4-point glycemic profiles performed at baseline and at 6 and 12 months. Two primary end points were tested in hierarchical order: HbA1c change at 12 months and percentage of patients at risk target for low and high blood glucose index. RESULTS: Intent-to-treat analysis showed greater HbA1c reductions over 12 months in ISM (-0.39%) than in AC patients (-0.27%), with a between-group difference of -0.12% (95% CI, -0.210 to -0.024; P=0.013). In the per-protocol analysis, the between-group difference was -0.21% (-0.331 to -0.089; P=0.0007). More ISM than AC patients achieved clinically meaningful reductions in HbA1c (>0.3, >0.4, or >0.5%) at study end (P<0.025). The proportion of patients reaching/maintaining the risk target at month 12 was similar in ISM (74.6%) and AC (70.1%) patients (P=0.131). At visits 2, 3, and 4, diabetes medications were changed more often in ISM than in AC patients (P<0.001). CONCLUSIONS: Use of structured SMBG improves glycemic control and provides guidance in prescribing diabetes medications in patients with relatively well-controlled noninsulin-treated type 2 diabetes. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/23735724; info:eu-repo/semantics/altIdentifier/wos/WOS:000324749500018; volume:36; issue:10; firstpage:2887; lastpage:2894; numberofpages:8; journal:DIABETES CARE; http://hdl.handle.net/11365/49350Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84889673528; https://diabetesjournals.org/care/article/36/10/2887/30627/Intensive-Structured-Self-Monitoring-of-BloodTest |
| DOI: | 10.2337/dc13-0092 |
| الإتاحة: | https://doi.org/10.2337/dc13-0092Test http://hdl.handle.net/11365/49350Test https://diabetesjournals.org/care/article/36/10/2887/30627/Intensive-Structured-Self-Monitoring-of-BloodTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F7A6CE62 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2337/dc13-0092 |
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