دورية أكاديمية
Left ventricular myocardial deformation abnormalities in arrhythmic mitral valve prolapse: which comes first?
| العنوان: | Left ventricular myocardial deformation abnormalities in arrhythmic mitral valve prolapse: which comes first? |
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| المؤلفون: | Cecere, A, De Lazzari, M, Cipriani, A, Giorgi, B, Motta, R, Iliceto, S, Perazzolo Marra, M |
| المصدر: | European Heart Journal - Cardiovascular Imaging ; volume 22, issue Supplement_2 ; ISSN 2047-2404 2047-2412 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine, Radiology, Nuclear Medicine and imaging, General Medicine |
| الوصف: | Funding Acknowledgements Type of funding sources: None. Background. Arrhythmic mitral valve prolapse (MVP) is characterized by left ventricular (LV) fibrosis in the basal inferolateral wall and papillary muscles. We hypothesized that LV fibrosis are driven by excessive mechanical forces acting on myocardial susceptible cells, representing the last step in the MVP-induced myocardial stretch process. Purpose. We aimed to evaluate the LV myocardial deformation, using strain assessed with cardiac magnetic resonance (CMR), in arrhythmic MVP patients with normal LV ejection fraction (LVEF) and absent/trivial mitral regurgitation (MR) and its correlation with the presence of LV fibrosis, detected by late gadolinium enhancement (LGE) in post-contrast CMR images. Methods. We enrolled consecutive arrhythmic MVP patients with normal LVEF and no/trivial MR. Sixty-nine (39 female; median age: 40 years) patients without MVP, arrhythmias or cardiovascular history served as control group. All patients underwent CMR for identification of LGE and evaluation of LV myocardial deformation. Results. A total of 66 patients were enrolled (47 female; median age: 44 years). In the overall MVP population, LGE was present in 41 patients (62.1%). MVP patients without LGE (25 patients, 37.9%) presented a higher global radial (median: 42.19 vs 33; p: <0.0001) and higher global longitudinal strain (median: -21.61 vs -18.10; p: <0.0001), compared to the control group. A reduction of regional basal posterolateral radial (BPL median: 50.60 vs 67.30; p: 0.0015) and longitudinal strain (BPL median: -23.50 vs -26.70; p: 0.0186) were observed in the MVP patients as compared with controls (Figures A-D). Conversely to the basal region, mid anterolateral and posterolateral region presented a higher radial (MAL median: 52.60 vs 31.10; p: < 0.0001 and MPL median: 52.80 vs 21.50; p: < 0.0001) and longitudinal strain (MAL median: -24.80 vs -18.30; p: < 0.0001 and MPL median: -25.30 vs -14.80; p: < 0.0001), ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ehjci/jeab090.047 |
| الإتاحة: | https://doi.org/10.1093/ehjci/jeab090.047Test http://academic.oup.com/ehjcimaging/article-pdf/22/Supplement_2/jeab090.047/38937903/jeab090.047.pdfTest |
| حقوق: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelTest |
| رقم الانضمام: | edsbas.F783E427 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ehjci/jeab090.047 |
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