دورية أكاديمية
Development of monoclonal gammopathy under biotherapy in psoriasis: a French multicenter retrospective study.
| العنوان: | Development of monoclonal gammopathy under biotherapy in psoriasis: a French multicenter retrospective study. |
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| المؤلفون: | Liegeon, Anne-Laure, Mahé, Emmanuel, Begon, Edouard, Poreaux, Claire, Barbaud, Annick, Estève, Eric, Quiles-Tsimaratos, Nathalie, Avenel-Audran, Martine, Schoeffler, Amélie, Mery-Bossard, Laure, Pauwels, Christine, Girard, Céline, Maillard, Hervé, Barthelme, Dominique, Bernier, Claire, Chaby, Guillaume, Reguiai, Ziad, Nguyen-Thi, Phi Linh, Maccari, François, Schmutz, Jean-Luc |
| المساهمون: | Service de Dermatologie et Allergologie CHRU Nancy, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Hospitalier Victor Dupouy, Centre Hospitalier René Dubos Pontoise, Département de Dermatologie, Centre Hospitalier Régional d'Orléans (CHRO), Hôpital Saint-Joseph Marseille, Département de dermatologie, CHU Angers, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Centre hospitalier régional Metz-Thionville (CHR Metz-Thionville), Centre hospitalier F. Quesnay, CHI Poissy-Saint-Germain, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Service de dermatologie CH Le Mans, Centre Hospitalier Le Mans (CH Le Mans), Centre hospitalier de Pau, Service de dermatologie Nantes, Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), Service de dermatologie CHU d'Amiens-Picardie, CHU Amiens-Picardie, Département de Dermatologie CHU de Reims, Centre Hospitalier Universitaire de Reims (CHU Reims), Service d'Epidémiologie et Evaluations Cliniques CHRU Nancy (Pôle S2R), Hôpital d'Instruction des Armées Begin, Service de Santé des Armées |
| المصدر: | ISSN: 1167-1122. |
| بيانات النشر: | HAL CCSD John Libbey Eurotext |
| سنة النشر: | 2016 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | biotherapy, monoclonal gammopathy, psoriasis, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience ; BACKGROUND:Biotherapies or targeted therapies are fairly new treatments indicated for moderate to severe psoriasis. The side effects appear to be mainly infectious or cancerous. The role of biotherapies in the development of a pre-cancerous condition, monoclonal gammopathy of undetermined significance (MGUS), has recently been debated in the literature.OBJECTIVES:To evaluate the incidence of MGUS in psoriasis patients treated with biotherapy.MATERIALS AND METHODS:This study was a French multicenter retrospective study carried out through the French multicenter study group RESOPSO. Data on the results of serum protein electrophoreses performed before and within at least six months after the start of the biotherapy were collected. Demographic data, medical history, and psoriasis treatment history were specified.RESULTS:Four hundred and forty three patients were eligible for inclusion. Of these, three presented with monoclonal gammopathy for which the assessment was in favor of MGUS. The average treatment period was 19.7 months. Six patients presented with MGUS prior to the treatment. These patients' immunoglobulin levels remained stable, with an average remission of 24 months. Only psoriatic rheumatism appeared to be statistically linked to MGUS.CONCLUSION:The incidence and frequency of MGUS in psoriasis patients treated with biotherapy do not appear to increase relative to the general population. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/26878712; hal-01989348; https://hal.umontpellier.fr/hal-01989348Test; PUBMED: 26878712 |
| DOI: | 10.1684/ejd.2015.2700 |
| الإتاحة: | https://doi.org/10.1684/ejd.2015.2700Test https://hal.umontpellier.fr/hal-01989348Test |
| رقم الانضمام: | edsbas.F729AF29 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1684/ejd.2015.2700 |
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