التفاصيل البيبلوغرافية
| العنوان: |
Cellular Therapy for Children with Central Nervous System Tumors: Mining and Mapping the Correlative Data |
| المؤلفون: |
Crotty, Erin E., Wilson, Ashley L., Davidson, Tom, Tahiri, Sophia, Gust, Juliane, Griesinger, Andrea M., Venkataraman, Sujatha, Park, Julie R., Mueller, Sabine, Rood, Brian R., Hwang, Eugene I., Wang, Leo D., Vitanza, Nicholas A. |
| المصدر: |
Current Oncology Reports ; volume 25, issue 8, page 847-855 ; ISSN 1523-3790 1534-6269 |
| بيانات النشر: |
Springer Science and Business Media LLC |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
Oncology |
| الوصف: |
Purpose of Review Correlative studies should leverage clinical trial frameworks to conduct biospecimen analyses that provide insight into the bioactivity of the intervention and facilitate iteration toward future trials that further improve patient outcomes. In pediatric cellular immunotherapy trials, correlative studies enable deeper understanding of T cell mobilization, durability of immune activation, patterns of toxicity, and early detection of treatment response. Here, we review the correlative science in adoptive cell therapy (ACT) for childhood central nervous system (CNS) tumors, with a focus on existing chimeric antigen receptor (CAR) and T cell receptor (TCR)-expressing T cell therapies. Recent Findings We highlight long-standing and more recently understood challenges for effective alignment of correlative data and offer practical considerations for current and future approaches to multi-omic analysis of serial tumor, serum, and cerebrospinal fluid (CSF) biospecimens. We highlight the preliminary success in collecting serial cytokine and proteomics from patients with CNS tumors on ACT clinical trials. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1007/s11912-023-01423-3 |
| DOI: |
10.1007/s11912-023-01423-3.pdf |
| DOI: |
10.1007/s11912-023-01423-3/fulltext.html |
| الإتاحة: |
https://doi.org/10.1007/s11912-023-01423-3Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: |
edsbas.F6D5454D |
| قاعدة البيانات: |
BASE |
