دورية أكاديمية
Does lumbar spinal degeneration begin with the anterior structures? A study of the observed epidemiology in a community-based population
| العنوان: | Does lumbar spinal degeneration begin with the anterior structures? A study of the observed epidemiology in a community-based population |
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| المؤلفون: | Jarvik Jeffrey G, Hunter David J, Miyakoshi Asako, Suri Pradeep, Rainville James, Guermazi Ali, Li Ling, Katz Jeffrey N |
| المصدر: | BMC Musculoskeletal Disorders, Vol 12, Iss 1, p 202 (2011) |
| بيانات النشر: | BMC |
| سنة النشر: | 2011 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | degenerative cascade, degeneration, disk, facet joint, arthritis, lumbar, spine, Diseases of the musculoskeletal system, RC925-935 |
| الوصف: | Background- Prior studies that have concluded that disk degeneration uniformly precedes facet degeneration have been based on convenience samples of individuals with low back pain. We conducted a study to examine whether the view that spinal degeneration begins with the anterior spinal structures is supported by epidemiologic observations of degeneration in a community-based population. Methods- 361 participants from the Framingham Heart Study were included in this study. The prevalences of anterior vertebral structure degeneration (disk height loss) and posterior vertebral structure degeneration (facet joint osteoarthritis) were characterized by CT imaging. The cohort was divided into the structural subgroups of participants with 1) no degeneration, 2) isolated anterior degeneration (without posterior degeneration), 3) combined anterior and posterior degeneration, and 4) isolated posterior degeneration (without anterior structure degeneration). We determined the prevalence of each degeneration pattern by age group < 45, 45-54, 55-64, ≥65. In multivariate analyses we examined the association between disk height loss and the response variable of facet joint osteoarthritis, while adjusting for age, sex, BMI, and smoking. Results- As the prevalence of the no degeneration and isolated anterior degeneration patterns decreased with increasing age group, the prevalence of the combined anterior/posterior degeneration pattern increased. 22% of individuals demonstrated isolated posterior degeneration, without an increase in prevalence by age group. Isolated posterior degeneration was most common at the L5-S1 and L4-L5 spinal levels. In multivariate analyses, disk height loss was independently associated with facet joint osteoarthritis, as were increased age (years), female sex, and increased BMI (kg/m 2 ), but not smoking. Conclusions- The observed epidemiology of lumbar spinal degeneration in the community-based population is consistent with an ordered progression beginning in the anterior structures, for the ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1471-2474 |
| العلاقة: | http://www.biomedcentral.com/1471-2474/12/202Test; https://doaj.org/toc/1471-2474Test; https://doaj.org/article/50f094e9d852491884894fdbcfb8520aTest |
| DOI: | 10.1186/1471-2474-12-202 |
| الإتاحة: | https://doi.org/10.1186/1471-2474-12-202Test https://doaj.org/article/50f094e9d852491884894fdbcfb8520aTest |
| رقم الانضمام: | edsbas.F6247FAA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14712474 |
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| DOI: | 10.1186/1471-2474-12-202 |