التفاصيل البيبلوغرافية
| العنوان: |
Impact of IDH Mutations, the 1p/19q Co-Deletion and the G-CIMP Status on Alternative Splicing in Diffuse Gliomas |
| المؤلفون: |
Lu Zhang, Sabrina Fritah, Petr V. Nazarov, Tony Kaoma, Eric Van Dyck |
| المصدر: |
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 9825 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
diffuse gliomas, isocitrate dehydrogenase (IDH), 1p/19q co-deletion, G-CIMP, pre-mRNA splicing, alternative splicing, differential gene expression, epigenetic regulation |
| جغرافية الموضوع: |
agris |
| الوصف: |
By generating protein diversity, alternative splicing provides an important oncogenic pathway. Isocitrate dehydrogenase (IDH) 1 and 2 mutations and 1p/19q co-deletion have become crucial for the novel molecular classification of diffuse gliomas, which also incorporates DNA methylation profiling. In this study, we have carried out a bioinformatics analysis to examine the impact of the IDH mutation, as well as the 1p/19q co-deletion and the glioma CpG island methylator phenotype (G-CIMP) status on alternative splicing in a cohort of 662 diffuse gliomas from The Cancer Genome Atlas (TCGA). We identify the biological processes and molecular functions affected by alternative splicing in the various glioma subgroups and provide evidence supporting the important contribution of alternative splicing in modulating epigenetic regulation in diffuse gliomas. Targeting the genes and pathways affected by alternative splicing might provide novel therapeutic opportunities against gliomas. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Molecular Oncology; https://dx.doi.org/10.3390/ijms24129825Test |
| DOI: |
10.3390/ijms24129825 |
| الإتاحة: |
https://doi.org/10.3390/ijms24129825Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.F5EE24F6 |
| قاعدة البيانات: |
BASE |
