مؤتمر
Brief Report: Long-Term (96-Week) Efficacy and Safety After Switching From Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in HIV-Infected, Virologically Suppressed Adults.
| العنوان: | Brief Report: Long-Term (96-Week) Efficacy and Safety After Switching From Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in HIV-Infected, Virologically Suppressed Adults. |
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| المؤلفون: | Raffi, F, Orkin, C, Clarke, A, Slama, L, Gallant, J, Daar, E, Henry, K, Santana-Bagur, J, Stein, DK, Bellos, N, Scarsella, A, Yan, M, Abram, ME, Cheng, A, Rhee, MS |
| سنة النشر: | 2017 |
| المجموعة: | Queen Mary University of London: Queen Mary Research Online (QMRO) |
| مصطلحات موضوعية: | Adenine, Anti-HIV Agents, CD4 Lymphocyte Count, Double-Blind Method, HIV Infections, HIV-1, Humans, Middle Aged, Tenofovir, Treatment Outcome, Viral Load |
| الوصف: | In a double-blind, phase 3 trial, 663 HIV-infected, virologically suppressed adults were randomized to switch to tenofovir alafenamide (TAF; n = 333) vs. remain on tenofovir disoproxil fumarate (TDF; n = 330), each coformulated with emtricitabine (FTC), while continuing their third agent (boosted protease inhibitor or unboosted third agent). At week 96, 88.6% on FTC/TAF and 89.1% on FTC/TDF had HIV-1 RNA <50 copies per milliliter [adjusted difference -0.5% (95% confidence interval: -5.3 to 4.4%)]. Proteinuria, albuminuria, proximal renal tubular function, and bone mineral density improved after switching to TAF- from TDF-containing regimens. These longer-term data support FTC/TAF as a safe, well-tolerated, and durable nucleotide reverse transcriptase inhibitor backbone. ; This study was sponsored by Gilead Sciences, Inc. (Gilead) |
| نوع الوثيقة: | conference object |
| وصف الملف: | 226 - 231 |
| اللغة: | English |
| العلاقة: | https://qmro.qmul.ac.uk/xmlui/handle/123456789/63526Test |
| DOI: | 10.1097/QAI.0000000000001344 |
| الإتاحة: | https://doi.org/10.1097/QAI.0000000000001344Test https://qmro.qmul.ac.uk/xmlui/handle/123456789/63526Test |
| حقوق: | CC-NC ND ; Attribution-NonCommercial-NoDerivs 3.0 United States ; http://creativecommons.org/licenses/by-nc-nd/3.0/usTest/ ; 2017 The Author(s). |
| رقم الانضمام: | edsbas.F5B0D6BD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/QAI.0000000000001344 |
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