دورية أكاديمية
Long-term results of pediatric liver transplantation for autoimmune liver disease.
| العنوان: | Long-term results of pediatric liver transplantation for autoimmune liver disease. |
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| المؤلفون: | Couchonnal, E., Jacquemin, E., Lachaux, A., Ackermann, O., Gonzales, E., Lacaille, F., Debray, D., Boillot, O., Guillaud, O., Wildhaber, B.E., Chouik, Y., McLin, V., Dumortier, J. |
| المصدر: | Clinics and research in hepatology and gastroenterology, vol. 45, no. 3, pp. 101537 |
| سنة النشر: | 2021 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Child, Cholangitis, Sclerosing, End Stage Liver Disease, Female, Hepatitis, Autoimmune/surgery, Humans, Liver Transplantation, Male, Retrospective Studies, Auto-immune disease, Outcome, Pediatric, Survival |
| الوصف: | Autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC) are rare indications for liver transplantation (LT) in children. The aim of the present retrospective multicenter study was to evaluate long-term outcome after LT for autoimmune liver disease in childhood. Retrospective data from 30 children who underwent a first LT from 1988 to 2018 were collected. The study population consisted of 18 girls and 12 boys, transplanted for AIH type 1 (n=14), AIH type 2 (n=7) or PSC (n=9). Mean age at LT was 11.8±5.2 years. The main indications for LT were acute (36.7%) or chronic end-stage liver failure (63.3%). Graft rejection occurred in 19 patients (63.3%); 6 pts required retransplantation for chronic rejection. Recurrence of initial disease was observed in 6 patients (20.0%), all of them with type 1 AIH, after a median time of 42 months, requiring retransplantation in 2 cases. Overall patient survival rates were 96.4%, 84.6%, 74.8%, 68.0%, 68.0%, 68.0% and 68.0% at 1, 5, 10, 15, 20, 25 and 30 years, respectively. Age at LT<1year (p<0.0001), LT for fulminant failure (p=0.023) and LT for type 2 AIH (p=0.049) were significant predictive factors of death. Long-term outcome after LT for pediatric autoimmune liver disease is impaired in patients with AIH because of consistent complications such as rejection and disease recurrence. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2210-7401 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33077391; info:eu-repo/semantics/altIdentifier/eissn/2210-741X; https://serval.unil.ch/notice/serval:BIB_AF7E7254A233Test; urn:issn:2210-7401 |
| DOI: | 10.1016/j.clinre.2020.08.013 |
| الإتاحة: | https://doi.org/10.1016/j.clinre.2020.08.013Test https://serval.unil.ch/notice/serval:BIB_AF7E7254A233Test |
| رقم الانضمام: | edsbas.F58E4BCF |
| قاعدة البيانات: | BASE |
| تدمد: | 22107401 |
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| DOI: | 10.1016/j.clinre.2020.08.013 |