التفاصيل البيبلوغرافية
| العنوان: |
A PSE APPROACH FOR YIELD ENHANCEMENT IN BIOPROCESSING |
| المؤلفون: |
Eyal Dassau, Israel Zadok, Daniel R. Lewin |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
http://tx.technion.ac.il/~dlewin/publications/Fosbe_Dassau_V6.pdfTest. |
| المجموعة: |
CiteSeerX |
| مصطلحات موضوعية: |
Bioprocessing, Six-sigma, Yield Enhancement and Downstream Proc- essing |
| الوصف: |
Improving the sigma level of a pharmaceutical process leads to reduced cycle times, and increased over-all efficiency and quality. These objectives can be achieved using an approach involving: (a) Process Analytical Technologies (PAT), for data extraction; (b) Six-sigma methodology that serves as the driving force for continuous improvement by identifying the root cause or causes of low process yield; (c) Process modeling, based on systems biology and first principles models; and (d) Advanced process control (APC) and statistical process control (SPC). This methodology is demonstrated on a simplified process for the production of penicillin including a fermentor and the first of the downstream processing steps. We show that a combination of improved process control in the downstream processing sections as well as a modified substrate feeding profile in the fermentor, can together achieve a 40 % reduction in batch time while at the same time significantly increasing throughput yield. Evidently, this systematic approach can make a substantial impact in the pharmaceutical industry, through improved overall process yield, quality and return on investment. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.615.5939Test; http://tx.technion.ac.il/~dlewin/publications/Fosbe_Dassau_V6.pdfTest |
| الإتاحة: |
http://tx.technion.ac.il/~dlewin/publications/Fosbe_Dassau_V6.pdfTest |
| حقوق: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.F56F5BBC |
| قاعدة البيانات: |
BASE |
