دورية أكاديمية
eTICI reperfusion: defining success in endovascular stroke therapy.
| العنوان: | eTICI reperfusion: defining success in endovascular stroke therapy. |
|---|---|
| المؤلفون: | Liebeskind, David S, Bracard, Serge, Guillemin, Francis, Jahan, Reza, Jovin, Tudor G, Majoie, Charles Blm, Mitchell, Peter J, van der Lugt, Aad, Menon, Bijoy K, San Román, Luis, Campbell, Bruce Cv, Muir, Keith W, Hill, Michael D, Dippel, Diederik Wj, Saver, Jeffrey L, Demchuk, Andrew M, Dávalos, Antoni, White, Philip, Brown, Scott, Goyal, Mayank, Baxter, Blaise W, MD |
| المصدر: | Department of Radiology & Diagnostic Medical Imaging |
| بيانات النشر: | LVHN Scholarly Works |
| سنة النشر: | 2019 |
| المجموعة: | Lehigh Valley Health Network: LVHN Scholarly Works |
| مصطلحات موضوعية: | Aged, Carotid Artery, Internal, Cerebral Angiography, Cerebral Revascularization, Endovascular Procedures, Female, Fibrinolytic Agents, Humans, Male, Middle Aged, Middle Cerebral Artery, Reperfusion, Stroke, Thrombolytic Therapy, Tissue Plasminogen Activator, Treatment Outcome, Department of Radiology and Diagnostic Medical Imaging, Diagnosis, Medicine and Health Sciences, Other Analytical, Diagnostic and Therapeutic Techniques and Equipment, Radiology |
| الوصف: | BACKGROUND: Revascularization after endovascular therapy for acute ischemic stroke is measured by the Thrombolysis In Cerebral Infarction (TICI) scale, yet variability exists in scale definitions. We examined the degree of reperfusion with the expanded TICI (eTICI) scale and association with outcomes in the HERMES collaboration of recent endovascular trials. METHODS: The HERMES Imaging Core, blind to all other data, evaluated angiography after endovascular therapy in HERMES. A battery of TICI scores (mTICI, TICI, TICI2C) was used to define reperfusion of the initial target occlusion defined by non-invasive imaging and conventional angiography. RESULTS: Angiography of 801 subjects was available, including 797 defined by non-invasive imaging (154 internal carotid artery (ICA), 583 M1, 60 M2) and 748 by conventional angiography (195 ICA, 459 M1, 94 M2). Among 729 subjects in whom the reperfusion grade could be established, using eTICI (3=100%, 2C=90-99%, 2b67=67-89%, 2b50=50-66%) of the conventional angiography target occlusion, there were 63 eTICI 3 (9%), 166 eTICI 2c (23%), 218 eTICI 2b67 (30%), 103 eTICI 2b50 (14%), 100 eTICI 2a (14%), 19 eTICI 1 (3%), and 60 eTICI 0 (8%). Modified Rankin Scale shift analyses from baseline to 90 days showed that increasing TICI grades were linked with better outcomes, with significant distinctions between TICI 0/1 versus 2a (p=0.028), 2a versus 2b50 (p=0.017), and 2b50 versus 2b67 (p=0.014). CONCLUSIONS: The benefit of endovascular therapy in HERMES was strongly associated with increasing degrees of reperfusion defined by eTICI. The eTICI metric identified meaningful distinctions in clinical outcomes and may be used in future studies and routine practice. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://scholarlyworks.lvhn.org/radiology-diagnostic-medical-imaging/1058Test; https://pubmed.ncbi.nlm.nih.gov/30194109Test/ |
| الإتاحة: | https://scholarlyworks.lvhn.org/radiology-diagnostic-medical-imaging/1058Test https://pubmed.ncbi.nlm.nih.gov/30194109Test/ |
| رقم الانضمام: | edsbas.F5548A86 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |