دورية أكاديمية
Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
| العنوان: | Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude |
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| المؤلفون: | Kadalayil, L., Alam, M., White, C., Ghantous, A., Walton, E., Gruzieva, O., Merid, S., Kumar, A., Roy, R., Solomon, O., Huen, K., Eskenazi, B., Rzehak, P., Grote, V., Langhendries, J., Verduci, E., Ferre, N., Gruszfeld, D., Gao, L., Guan, W., Zeng, X., Schisterman, E., Dou, J., Bakulski, K., Feinberg, J., Soomro, M., Pesce, G., Baiz, N., Isaevska, E., Plusquin, M., Vafeiadi, M., Roumeliotaki, T., Langie, S., Standaert, A., Allard, C., Perron, P., Bouchard, L., van Meel, E., Felix, J., Jaddoe, V., Yousefi, P., Ramlau-Hansen, C., Relton, C., Tobi, E., Starling, A., Yang, I., Llambrich, M., Santorelli, G., Lepeule, J., Salas, L., Bustamante, M., Ewart, S., Zhang, H., Karmaus, W., Roeder, S., Zenclussen, A., Jin, J., Nystad, W., Page, C., Magnus, M., Jima, D., Hoyo, C., Maguire, R., Kvist, T., Czamara, D., Raikkonen, K., Gong, T., Ullemar, V., Rifas-Shiman, S., Oken, E., Almqvist, C., Karlsson, R., Lahti, J., Murphy, S., Haberg, S., London, S., Herberth, G., Arshad, H., Sunyer, J., Grazuleviciene, R., Dabelea, D., Steegers-Theunissen, R., Nohr, E., Sorensen, T., Duijts, L., Hivert, M., Nelen, V., Popovic, M., Kogevinas, M., Nawrot, T., Herceg, Z., Annesi-Maesano, I., Fallin, M., Yeung, E., Breton, C., Koletzko, B., Holland, N., Wiemels, J., Melen, E., Sharp, G., Silver, M., Rezwan I, F., Holloway, J. |
| المصدر: | CLINICAL EPIGENETICS |
| سنة النشر: | 2023 |
| المجموعة: | Max Planck Society: MPG.PuRe |
| الوصف: | Background Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms underlying the associations between birth season and lifelong phenotypes remains unclear. Methods We carried out epigenome-wide meta-analyses within the Pregnancy And Childhood Epigenetic Consortium to identify associations of DNAm with birth season, both at differentially methylated probes (DMPs) and regions (DMRs). Associations were examined at two time points: at birth (21 cohorts, N = 9358) and in children aged 1-11 years (12 cohorts, N = 3610). We conducted meta-analyses to assess the impact of latitude on birth season-specific associations at both time points. Results We identified associations between birth season and DNAm (False Discovery Rate-adjusted p values < 0.05) at two CpGs at birth (winter-born) and four in the childhood (summer-born) analyses when compared to children born in autumn. Furthermore, we identified twenty-six differentially methylated regions (DMR) at birth (winter-born: 8, spring-born: 15, summer-born: 3) and thirty-two in childhood (winter-born: 12, spring and summer: 10 each) meta-analyses with few overlapping DMRs between the birth seasons or the two time points. The DMRs were associated with genes of known functions in tumorigenesis, psychiatric/neurological disorders, inflammation, or immunity, amongst others. Latitude-stratified meta-analyses [higher (>= 50 degrees N), lower (< 50 degrees N, northern hemisphere only)] revealed differences in associations between birth season and DNAm by birth latitude. DMR analysis implicated genes with previously reported links to schizophrenia (LAX1), skin disorders (PSORS1C, LTB4R), and airway inflammation including asthma (LTB4R), present only at birth in the higher latitudes (>= 50 degrees N). Conclusions In this large epigenome-wide meta-analysis study, we provide evidence for (i) associations ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | http://hdl.handle.net/21.11116/0000-000D-DEC6-ATest |
| الإتاحة: | https://doi.org/10.1186/s13148-023-01542-5Test http://hdl.handle.net/21.11116/0000-000D-DEC6-ATest |
| رقم الانضمام: | edsbas.F5460A4C |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |