دورية أكاديمية
Predictors of type 2 diabetes relapse after Roux-en-Y Gastric Bypass: a ten-year follow-up study
| العنوان: | Predictors of type 2 diabetes relapse after Roux-en-Y Gastric Bypass: a ten-year follow-up study |
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| المؤلفون: | Moriconi, Diego, Manca, Maria Laura, Anselmino, Marco, Rebelos, Eleni, Bellini, Rosario, Taddei, Stefano, Ferrannini, Ele, Nannipieri, Monica |
| المساهمون: | Moriconi, Diego, Manca, Maria Laura, Anselmino, Marco, Rebelos, Eleni, Bellini, Rosario, Taddei, Stefano, Ferrannini, Ele, Nannipieri, Monica |
| سنة النشر: | 2021 |
| المجموعة: | ARPI - Archivio della Ricerca dell'Università di Pisa |
| مصطلحات موضوعية: | Bariatric surgery, Diabetes relapse, Gastric bypa, Obesity, Type 2 diabetes mellitu, Weight loss |
| الوصف: | Aims: To assess the impact of bariatric surgery on remission and relapse of type 2 diabetes mellitus (T2DM) at 10 years of follow-up and analyze predictive factors. Materials and methods: Eighty-eight obese subjects undergoing Roux-en-Y gastric bypass (RYGB) and 25 subjects assigned to medical therapy (MT) were evaluated every year for 10 years. T2DM remission was defined by the American Diabetes Association criteria. Results: Body mass index (BMI), fasting glucose, and hemoglobin A1c (HbA1c) improved more markedly in RYGB than MT patients throughout the 10-year period. Post-surgery remission rates were 74% and 53% at 1 and 10 years, respectively, while remission did not occur in MT patients. One-year post-surgery, BMI decreased more in subjects with remission than in those without, but no further decrease was observed thereafter. By partial-least-squares analysis, T2DM duration, baseline HbA1c, and ensuing insulin therapy were the strongest predictors of remission. Remission was achieved at one year in 91% of patients with T2DM duration < 4 years, and 79% of them remained in remission at 10 years. On the contrary only 42% of patients with T2DM duration ≥ 4 years achieved remission, which was maintained only in 6% at the end of 10 years. By survival analysis, patients with T2DM duration < 4 years had higher remission rates than those with duration ≥ 4 years (hazards ratio (HR) 3.1 [95%CI 1.8-5.7]). Relapse did not occur before two years post-surgery and was much less frequent in patients with < 4- vs ≥ 4-year duration (HR 11.8 [4.9-29.4]). Conclusions: Short T2DM duration and good glycemic control before RYGB surgery were the best requisites for a long-lasting T2DM remission, whereas weight loss had no impact on the long-term relapse of T2DM. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34547450; info:eu-repo/semantics/altIdentifier/wos/WOS:000758467500002; volume:48; issue:1; journal:DIABETES & METABOLISM; https://hdl.handle.net/11568/1112256Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85120858682; https://www.sciencedirect.com/science/article/pii/S1262363621000653Test |
| DOI: | 10.1016/j.diabet.2021.101282 |
| الإتاحة: | https://doi.org/10.1016/j.diabet.2021.101282Test https://hdl.handle.net/11568/1112256Test https://www.sciencedirect.com/science/article/pii/S1262363621000653Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F4F38108 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.diabet.2021.101282 |
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