دورية أكاديمية
The prognostic role of histomorphological subtyping in nonmetastatic papillary renal cell carcinoma after curative surgery: is subtype really irrelevant? A propensity score matching analysis of a multi-institutional real life data
| العنوان: | The prognostic role of histomorphological subtyping in nonmetastatic papillary renal cell carcinoma after curative surgery: is subtype really irrelevant? A propensity score matching analysis of a multi-institutional real life data |
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| المؤلفون: | Erdem, Selcuk, Bertolo, Riccardo, Campi, Riccardo, Capitanio, Umberto, Amparore, Daniele, Anceschi, Umberto, Mir, Maria Carme, Roussel, Eduard, Pavan, Nicola, Carbonara, Umberto, Kara, Onder, Klatte, Tobias, Marchioni, Michele, Pecoraro, Angela, Muselaers, Stijn, Marandino, Laura, Diana, Pietro, Borregales, Leonardo, Palumbo, Carlotta, Warren, Hannah, Wu, Zhenjie, Calio, Anna, Ciccarese, Chiara, Degirmenci, Enes, Aydin, Resat, Rebez, Giacomo, Schips, Luigi, Simone, Giuseppe, Minervini, Andrea, Serni, Sergio, Ozcan, Faruk |
| المساهمون: | Erdem, Selcuk, Bertolo, Riccardo, Campi, Riccardo, Capitanio, Umberto, Amparore, Daniele, Anceschi, Umberto, Mir, Maria Carme, Roussel, Eduard, Pavan, Nicola, Carbonara, Umberto, Kara, Onder, Klatte, Tobia, Marchioni, Michele, Pecoraro, Angela, Muselaers, Stijn, Marandino, Laura, Diana, Pietro, Borregales, Leonardo, Palumbo, Carlotta, Warren, Hannah, Wu, Zhenjie, Calio, Anna, Ciccarese, Chiara, Degirmenci, Ene, Aydin, Resat, Rebez, Giacomo, Schips, Luigi, Simone, Giuseppe, Minervini, Andrea, Serni, Sergio, Ozcan, Faruk |
| سنة النشر: | 2024 |
| المجموعة: | Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| مصطلحات موضوعية: | Histomorphological subtype, Nonmetastatic, Papillary renal cell carcinoma, Prognosis |
| الوصف: | Background and aim: The role of histomorphological subtyping is an issue of debate in papillary renal cell carcinoma (papRCC). This multi-institutional study investigated the prognostic role of histomorphological subtyping in patients undergoing curative surgery for nonmetastatic papRCC. Patients and methods: A total of 1,086 patients undergoing curative surgery were included from a retrospectively collected multi-institutional nonmetastatic papRCC database. The patients were divided into 2 groups based on histomorphological subtyping (type 1, n = 669 and type 2, n = 417). Furthermore, a propensity score-matching (PSM) cohort in 1:1 ratio (n = 317 for each subtype) was created to reduce the effect of potential confounding variables. The primary outcome of the study, the predictive role of histomorphological subtyping on the prognosis (recurrence free survival [RFS], cancer specific survival [CSS] and overall survival [OS]) in nonmetastatic papRCC after curative surgery, was investigated in both overall and PSM cohorts. Results: In overall cohort, type 2 group were older (66 vs. 63 years, P = 0.015) and more frequently underwent radical nephrectomy (37.4% vs. 25.6%, P < 0.001) and lymphadenectomy (22.3% vs. 15.1%, P = 0.003). Tumor size (4.5 vs. 3.8 cm, P < 0.001) was greater, and nuclear grade (P < 0.001), pT stage (P < 0.001), pN stage (P < 0.001), VENUSS score (P < 0.001) and VENUSS high risk (P < 0.001) were significantly higher in type 2 group. 5-year RFS (89.6% vs. 74.2%, P < 0.001), CSS (93.9% vs. 84.2%, P < 0.001) and OS (88.5% vs. 78.5%, P < 0.001) were significantly lower in type 2 group. On multivariable analyses, type 2 was a significant predictor for RFS (HR:1.86 [95%CI:1.33-2.61], P < 0.001) and CSS (HR:1.91 [95%CI:1.20-3.04], P = 0.006), but not for OS (HR:1.27 [95%CI:0.92-1.76], P = 0.150). In PSM cohort balanced with age, gender, symptoms at diagnosis, pT and pN stages, tumor grade, surgical margin status, sarcomatoid features, rhabdoid features, and presence of ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/38443238; volume:42; issue:5; firstpage:1; lastpage:13; numberofpages:13; journal:UROLOGIC ONCOLOGY; https://hdl.handle.net/11562/1121167Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85186664588 |
| DOI: | 10.1016/j.urolonc.2024.01.028 |
| الإتاحة: | https://doi.org/10.1016/j.urolonc.2024.01.028Test https://hdl.handle.net/11562/1121167Test |
| رقم الانضمام: | edsbas.F4EBED32 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.urolonc.2024.01.028 |
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