دورية أكاديمية
Body mass index and lung cancer risk: a pooled analysis based on nested case-control studies from four cohort studies
| العنوان: | Body mass index and lung cancer risk: a pooled analysis based on nested case-control studies from four cohort studies |
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| المؤلفون: | Sanikini, Harinakshi, Yuan, Jian-Min, Butler, Lesley M., Koh, Woon-Puay, Gao, Yu-Tang, Steffen, Annika, Johansson, Mattias, Vineis, Paolo, Goodman, Gary E., Barnett, Matt J., Hung, Rayjean J., Chen, Chu, Stücker, Isabelle |
| المساهمون: | Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE)-Pennsylvania Commonwealth System of Higher Education (PCSHE), Duke-NUS Medical School Singapore, Saw Swee Hock School of Public Health, National University of Singapore (NUS), Department of Epidemiology, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DifE), Leibniz Association, Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Imperial College London, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center Seattle (FHCRC), Lunenfeld-Tanenbaum Research Institute Toronto, Canada, This work was supported by the Fondation de France and Ecole doctarale de Sante Publique (ED420). The EPIC study has been supported by the Europe Against Cancer Program of the European Commission. The SCHS and SCS were supported by NCI, NIH grants U01-CA63673, UM1-CA167462 and R01-CA111703. The CARET was supported by the National Institute of Health (U01 CA63673) and the Fred Hutchinson Cancer Research Center, Seattle, WA. |
| المصدر: | ISSN: 1471-2407. |
| بيانات النشر: | HAL CCSD BioMed Central |
| سنة النشر: | 2018 |
| المجموعة: | Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| مصطلحات موضوعية: | Lung cancer, Body mass index, Obesity, Overweight, [SDV]Life Sciences [q-bio], [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| الوصف: | International audience ; Background. Obesity has been proposed as a potential protective factor against lung cancer. We examined the association between BMI and lung cancer risk in a pooled analysis based on nested case-control studies from four cohort studies.Methods. A case-control study was nested within four cohorts in USA, Europe, China and Singapore that included 4172 cases and 8471 control subjects. BMI at baseline was calculated as weight in kilograms divided by height in meters squared (kg/m2), and classified into 4 categories: underweight (BMI < 18.5), normal weight (18.5 ≤ BMI < 25), overweight (25 ≤ BMI < 30) and obese (≥30). Odds ratios (ORs) and 95% confidence intervals (CIs) for BMI-lung cancer associations were estimated using unconditional logistic regression, adjusting for potential confounders.Results. Considering all participants, and using normal weight as the reference group, a decreased risk of lung cancer was observed for those who were overweight (OR 0.77, 95% CI: 0.68–0.86) and obese (OR 0.69, 95% CI: 0.59–0.82). In the stratified analysis by smoking status, the decreased risk for lung cancer was observed among current, former and never smokers (P for interaction 0.002). The adjusted ORs for overweight and obese groups were 0.79 (95% CI: 0.68–0.92) and 0.75 (95% CI: 0.60–0.93) for current smokers, 0.70 (95% CI: 0.53–0.93) and 0.55 (95% CI: 0.37–0.80) for former smokers, 0.77 (95% CI: 0.59–0.99), and 0.71 (95% CI: 0.44–1.14) for never smokers, respectively. While no statistically significant association was observed for underweight subjects who were current smokers (OR 1.24, 95% CI: 0.98–1.58), former smokers (OR 0.27, 95% CI: 0.12–0.61) and never smokers (OR 0.83, 95% CI: 0.5.-1.28).Conclusion. The results of this study provide additional evidence that obesity is associated with a decreased risk of lung cancer. Further biological studies are needed to address this association. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29471809; inserm-01716890; https://inserm.hal.science/inserm-01716890Test; https://inserm.hal.science/inserm-01716890/documentTest; https://inserm.hal.science/inserm-01716890/file/12885_2018_Article_4124.pdfTest; PUBMED: 29471809 |
| DOI: | 10.1186/s12885-018-4124-0 |
| الإتاحة: | https://doi.org/10.1186/s12885-018-4124-0Test https://inserm.hal.science/inserm-01716890Test https://inserm.hal.science/inserm-01716890/documentTest https://inserm.hal.science/inserm-01716890/file/12885_2018_Article_4124.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.F4CF308B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12885-018-4124-0 |
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