دورية أكاديمية
Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU
| العنوان: | Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU |
|---|---|
| المؤلفون: | Caballol, Berta, Núñez-Ortiz, Andrea, Piqueras, Marta, Mesonero, Francisco, Zabana, Yamile, Fernández Clotet, Agnès, LEO-CARNERERO, EDUARDO |
| المساهمون: | Mesonero F Inflammatory Bowel Disease Unit, Department of Gastroenterology and Hepatology, Hospital Universitario Ramón y Cajal, Madrid, Spain. Zabana Y Hospital Universitario Mútua Terrassa, Terrassa, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain. Fernández-Clotet A, Caballol B Hospital Clínic Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain. Leo-Camarero E, Núñez-Ortiz A Hospital Universitario Virgen del Rocío, Sevilla, Spain. Piqueras M Consorcio Sanitari de Terrassa, Terrassa, Spain, Consorci Sanitari de Terrassa |
| المصدر: | Scientia |
| بيانات النشر: | Sage |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Azatioprina, Intestins - Inflamació, CHEMICALS AND DRUGS::Organic Chemicals::Sulfur Compounds::Thionucleosides::Azathioprine, DISEASES::Digestive System Diseases::Gastrointestinal Diseases::Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases::Enteritis::Ileitis::Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases::Pouchitis, DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation, COMPUESTOS QUÍMICOS Y DROGAS::compuestos orgánicos::compuestos de azufre::tionucleósidos::azatioprina, ENFERMEDADES::enfermedades del sistema digestivo::enfermedades gastrointestinales::enfermedades del sistema digestivo::enfermedades gastrointestinales::enfermedades intestinales::enteritis::ileítis::enfermedades del sistema digestivo::enfermedades gastrointestinales::enfermedades intestinales::reservoritis, ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::inflamación |
| الوصف: | Azathioprine; Immunosuppressants; Thiopurines ; Azatioprina; Inmunosupresores; Tiopurinas ; Azatioprina; Immunosupressors; Tiopurines ; Background: The usefulness of thiopurines has been poorly explored in pouchitis and other pouch disorders. Objective: To evaluate the effectiveness and safety of azathioprine as maintenance therapy in inflammatory pouch disorders. Design: This was a retrospective and multicentre study. Methods: We included patients diagnosed with inflammatory pouch disorders treated with azathioprine in monotherapy. Effectiveness was evaluated at 1year and in the long term based on normalization of stool frequency, absence of pain, faecal urgency or fistula discharge (clinical remission), or any improvement in these symptoms (clinical response). Endoscopic response was evaluated using the Pouchitis Disease Activity Index (PDAI). Results: In all, 63 patients were included [54% males; median age, 49 (28–77) years]. The therapy was used to treat pouchitis (n=37) or Crohn’s disease of the pouch (n=26). The rate of clinical response, remission and non-response at 12months were 52%, 30% and 18%, respectively. After a median follow-up of 23months (interquartile range 11–55), 19 patients (30%) were in clinical remission, and 45 (66%) stopped therapy. Endoscopic changes were evaluated in 19 cases. PDAI score decreased from 3 (range 2–4) to 1 (range 0–3). In all, 21 patients (33%) presented adverse events and 16 (25%) needed to stop therapy. Conclusion: Azathioprine may be effective in the long term for the treatment of inflammatory pouch disorders and could be included as a therapeutic option. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | pdf; application/pdf |
| اللغة: | English |
| تدمد: | 1756-2848 38445247 |
| العلاقة: | Therapeutic Advances in Gastroenterology;17; Mesonero F, Zabana Y, Fernández-Clotet A, Leo-Carnerero E, Caballol B, Núñez-Ortiz A et al. Effectiveness and safety of azathioprine for inflammatory pouch disorders: results from the RESERVO study of GETECCU. Therap Adv Gastroenterol. 2024 Mar 4;17.; https://hdl.handle.net/11351/11236Test |
| DOI: | 10.1177/17562848241234476 |
| الإتاحة: | https://doi.org/10.1177/17562848241234476Test https://hdl.handle.net/11351/11236Test |
| حقوق: | Attribution-NonCommercial 4.0 International ; http://creativecommons.org/licenses/by-nc/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F4A692A4 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17562848 38445247 |
|---|---|
| DOI: | 10.1177/17562848241234476 |