التفاصيل البيبلوغرافية
| العنوان: |
Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes |
| المؤلفون: |
Fujita, Ken-ichi, Ito, Misa, Irie, Midori, Harada, Kotaro, Fujiwara, Naoko, Ikeda, Yuya, Yoshioka, Hanae, Yamazaki, Tomohiro, Kojima, Masaki, Mikami, Bunzo, Mayeda, Akila, Masuda, Seiji |
| المساهمون: |
藤田, 賢一, 伊藤, 慶紗, 入江, みどり, 原田, 光太郎, 藤原, 奈央子, 池田, 宥哉, 吉岡, 英恵, 山崎, 智弘, 小島, 正樹, 三上, 文三, 前田, 明, 増田, 誠司 |
| بيانات النشر: |
Springer Nature |
| سنة النشر: |
2024 |
| المجموعة: |
Kyoto University Research Information Repository (KURENAI) / 京都大学学術情報リポジトリ |
| مصطلحات موضوعية: |
RNA transport, X-ray crystallography |
| الوصف: |
mRNAを核から細胞質へ輸送するバルクmRNA輸送体の構成因子を解明 がんの早期発見や予後の予測に役立つ可能性のある研究成果. 京都大学プレスリリース. 2024-01-16. ; mRNA export is an essential pathway for the regulation of gene expression. In humans, closely related RNA helicases, UAP56 and URH49, shape selective mRNA export pathways through the formation of distinct complexes, known as apo-TREX and apo-AREX complexes, and their subsequent remodeling into similar ATP-bound complexes. Therefore, defining the unidentified components of the apo-AREX complex and elucidating the molecular mechanisms underlying the formation of distinct apo-complexes is key to understanding their functional divergence. In this study, we identify additional apo-AREX components physically and functionally associated with URH49. Furthermore, by comparing the structures of UAP56 and URH49 and performing an integrated analysis of their chimeric mutants, we exhibit unique structural features that would contribute to the formation of their respective complexes. This study provides insights into the specific structural and functional diversification of these two helicases that diverged from the common ancestral gene Sub2. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
2041-1723 |
| العلاقة: |
https://www.kyoto-u.ac.jp/ja/research-news/2024-01-16-1Test; http://hdl.handle.net/2433/286644Test; Nature Communications; 15; 455 |
| الإتاحة: |
http://hdl.handle.net/2433/286644Test |
| حقوق: |
© The Author(s) 2024 ; This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.F49F4607 |
| قاعدة البيانات: |
BASE |
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