التفاصيل البيبلوغرافية
| العنوان: |
Increased Rate of Epigenetic Aging in Men Living With HIV Prior to Treatment |
| المؤلفون: |
Sehl, Mary E., Breen, Elizabeth Crabb, Shih, Roger, Chen, Larry, Wang, Ruibin, Horvath, Steve, Bream, Jay H., Duggal, Priya, Martinson, Jeremy, Wolinsky, Steven M., Martinez-Maza, Otoniel, Ramirez, Christina M., Jamieson, Beth D. |
| المساهمون: |
National Institutes of Health, Susan G. Komen |
| المصدر: |
Frontiers in Genetics ; volume 12 ; ISSN 1664-8021 |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2022 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| مصطلحات موضوعية: |
Genetics (clinical), Genetics, Molecular Medicine |
| الوصف: |
Background: Epigenetic aging is accelerated in tissues of persons living with HIV (PLWH) and may underlie the early onset of age-related illnesses. This study examines the rate-of-change in epigenetic age in PLWH following HIV infection but before HAART, using archived longitudinal samples from the Multicenter AIDS Cohort Study. Methods: DNA was isolated from cryopreserved peripheral blood mononuclear cells from 101 men living with HIV, with baseline visit <2.5 years after HIV seroconversion (Visit 1) and follow-up visit <1.5 years before the initiation of HAART (Visit 2), and 100 HIV-uninfected men matched on age and visits with comparable time intervals. DNA methylation (DNAm) age was estimated for five clocks (Pan-tissue, Extrinsic, Phenotypic, Grim, and Skin & Blood age), and a DNAm-based estimate of telomere length (DNAmTL). Multivariate linear regression models were used to examine baseline factors associated with rate-of-aging, defined as (DNAm age visit 2–DNAm age visit 1)/(age visit 2–age visit 1). Results: Epigenetic age increased approximately twice as fast in PLWH as uninfected controls (Pan-tissue, Extrinsic, and Phenotypic clocks). Shortening of DNAmTL was nearly 3-fold faster in PLWH than controls. Faster rate-of-aging was associated with HIV status (Pan-Tissue, Extrinsic, Phenotypic, and DNAmTL), white race (Extrinsic, DNAmTL), higher cumulative HIV viral load (Grim), and lower baseline DNAm age (Phenotypic, Skin & Blood). Conclusion: Epigenetic rates-of-aging were significantly faster for untreated PLWH. Our findings expand on the important impact of HIV infection on biologic aging, both in elevating epigenetic age and increasing the rate-of-aging in the years following infection. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fgene.2021.796547 |
| DOI: |
10.3389/fgene.2021.796547/full |
| الإتاحة: |
https://doi.org/10.3389/fgene.2021.796547Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.F417E3D7 |
| قاعدة البيانات: |
BASE |
