دورية أكاديمية
Fully Closed-Loop Insulin Delivery in Patients Undergoing Pancreatic Surgery.
| العنوان: | Fully Closed-Loop Insulin Delivery in Patients Undergoing Pancreatic Surgery. |
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| المؤلفون: | Krutkyte, Gabija, Roos, Jonathan, Schuerch, Daniel, Czerlau, Cecilia, Wilinska, Malgorzata E, Wuethrich, Patrick Y, Herzig, David, Hovorka, Roman, Vogt, Andreas P, Gloor, Beat, Bally, Lia |
| بيانات النشر: | Mary Ann Liebert Inc Department of Paediatrics //dx.doi.org/10.1089/dia.2022.0400 Diabetes Technol Ther |
| سنة النشر: | 2023 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Closed-loop glucose control, Diabetes technology, Pancreatic surgery, Perioperative glycemic control, Humans, Insulin, Blood Glucose, Hypoglycemic Agents, Blood Glucose Self-Monitoring, Diabetes Mellitus, Type 1, Insulin Infusion Systems, Regular, Human |
| الوصف: | The central role of pancreas in glucose regulation imposes high demands on perioperative glucose management in patients undergoing pancreatic surgery. In a post hoc subgroup analysis of a randomized controlled trial, we evaluated the perioperative use of subcutaneous (SC) fully closed-loop (FCL; CamAPS HX) versus usual care (UC) insulin therapy in patients undergoing partial or total pancreatic resection. Glucose control was compared using continuous glucose monitoring (CGM) metrics (% time with CGM values between 5.6 and 10.0 mmol/L and more). Over the time of hospitalization, FCL resulted in better glucose control than UC with more time spent in the target range 5.6-10.0 mmol/L (mean [standard deviation] % time in target 77.7% ± 4.6% and 41.1% ± 19.5% in FCL vs. UC subjects, respectively; mean difference 36.6% [95% confidence interval 18.5-54.8]), without increasing the risk of hypoglycemia. Findings suggest that an adaptive SC FCL approach effectively accommodated the highly variable insulin needs in patients undergoing pancreatic surgery. Clinical trials registration: ClinicalTrials.gov, NCT04361799. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Print-Electronic; application/pdf |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/346204Test |
| DOI: | 10.17863/CAM.93624 |
| الإتاحة: | https://doi.org/10.17863/CAM.93624Test https://www.repository.cam.ac.uk/handle/1810/346204Test |
| حقوق: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.F3B5002 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.93624 |
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